CAS: 37693-01-9; 2-(2,4-Dichlorobenzyl)-4-(2,4,4-Trimethylpentan-2-yl)Phenol

专利信息

专利号:US-9327264-B2
优先权日:2011-01-31
标 题 :Containerless synthesis of amorphous and nanophase organic materials
发明人：BENMORE CHRIS J; WEBER JOHANN R
权利人:BENMORE CHRIS J; WEBER JOHANN R; UCHICAGO ARGONNE LLC
摘要:The invention provides a method for producing a mixture of amorphous compounds, the method comprising supplying a solution containing the compounds; and allowing at least a portion of the solvent of the solution to evaporate while preventing the solute of the solution from contacting a nucleation point. Also provided is a method for transforming solids to amorphous material, the method comprising heating the solids in an environment to form a melt, wherein the environment contains no nucleation points; and cooling the melt in the environment.

专利号:US-2023322787-A1
优先权日:2020-08-12
标 题 :Process for preparing enantiomerically enriched jak inhibitors
发明人：WIEDEMANN SEAN; COWDEN CAMERON J; BAZINET PATRICK; KAVOURIS KATHRYN E; WU KUO-MING; LEWIS ROBERT S
权利人:CONCERT PHARMACEUTICALS INC
摘要:Certain aspects of the present invention are directed to improved processes for preparing enantiomerically enriched intermediates for the synthesis of ruxolitinib and deuterated forms of ruxolitinib. Certain aspects are also directed to deuterated intermediates useful in the synthesis of deuterated forms of ruxolitinib. Certain aspects are also directed to reaction mixtures for preparing enantiomerically enriched intermediates useful in the synthesis of ruxolitinib and deuterated forms of ruxolitinib.

专利号:WO-0032619-A1
优先权日:1998-11-30
标题:Methods and compositions for identification of inhibitors of ribosome assembly
发明人：DAMMEL CAROL S; WATSON JULIE C
权利人:RIBOGENE INC
摘要:The invention provides a means for identifying novel antibiotics by screening for compounds that inhibit bacterial ribosome assembly and ribosomal protein synthesis, which comprises the screening of test compounds to identify those that inhibit the activity of a bacterial ribosomal protein. The in vitro and in vivo assays detect (a) increased translation of a reporter mRNA that is normally repressed in the presence of a ribosomal protein, (b) increased growth in cells that over-express ribosomal protein, and (c) decreased binding of the ribosomal protein to its target RNA. The invention encompasses the (a) methods of screening and testing compounds by the above methods, (b) compounds that are identified in the assay which inhibit ribosome assembly and protein synthesis and (c) methods for treatment using said compounds.

专利号:US-2012197005-A1
优先权日:2011-01-31
标题 :Containerless synthesis of amorphous and nanophase organic materials