CAS: 2657-25-2; 1-(4-Hydroxyphenyl)-3-Phenylprop-2-En-1-One

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CAS号100-52-7 苯甲醛 | CAS号99-93-4 对羟基苯乙酮 | CAS号22966-19-4 4'-Methoxychalcone | CAS号16162-69-9 1-[4-[(四氢-2H-吡喃... | CAS号140-10-3 肉桂酸 | CAS号108-95-2 苯酚 | CAS号2757-04-2 phenyl (E)-3-ph... | CAS号19882-38-3 2-[4-(2-phenyle... | CAS号614-47-1 反-查耳酮 | CAS号100-52-7 苯甲醛 | CAS号99-93-4 对羟基苯乙酮 | CAS号2515-57-3 Phenol,4-(4,5-d... | CAS号21148-30-1 Phenol,4-[(2E)-... | CAS号64820-41-3 4-(2-phenyl-3,5... | CAS号61078-51-1 2-[3-(4-hydroxy... | CAS号61270-17-5 1-[2-hydroxy-5-...

📜3-Phenyl-1-(4-Propan-2-Yloxyphenyl)Prop-2-En-1-One置于三氯化硼体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,以100%的收率获得4-羟基查耳酮
参考文献:Toxicity Assessments Of Chalcone And Some Synthetic Chalcone Analogues In A Zebrafish Model
标题:Toxicity Assessments Of Chalcone And Some Synthetic Chalcone Analogues In A Zebrafish Model
摘要:本研究旨在调查一些新型合成查耳酮的体内毒性.研究人员使用斑马鱼胚胎对查尔酮和四种查尔酮类似物 1A-D 进行了评估,通过抗体染色观察它们的形态变化和肌纤维排列.结果表明,用 3'-Hydroxy Chalcone(化合物 1B)处理的胚胎显示出很高比例的肌肉缺陷(96.6%),尤其是肌纤维错位.超微结构分析表明,经化合物 1B 处理的胚胎显示出许多肌肉缺陷表型,包括肌原纤维断裂和塌陷,细胞数量减少以及粗(肌球蛋白)丝和细(肌动蛋白)丝紊乱.综上所述,我们的研究结果为合成的查尔酮类似物对发育中的斑马鱼胚胎的肌毒性作用提供了体内证据.
Doi:10.3390/molecules19010641

专利信息

专利号:US-2016374997-A1
优先权日:2015-02-02
标题 :Antibiotic compounds that inhibit bacterial protein synthesis
发明人：BULLARD JAMES M; HU YANMEI; PALMER STEPHANIE O
权利人:UNIV TEXAS; UNIV TEXAS
摘要:An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.

专利号:US-2007128658-A1
优先权日:2005-11-14
标 题:Fluorescent dyes, methods and uses thereof
发明人：BLACKWELL HELEN E; BOWMAN MATTHEW D
权利人:BLACKWELL HELEN E; BOWMAN MATTHEW D
摘要:The present invention provides a method for identifying and characterizing candidate fluorescent molecules. This method involves the generation of spatially addressed arrays of heterocyclic compounds which are candidate fluorescent molecules. The spatially addressed array can be used to identify fluorescent molecules among the candidate molecules. The spatially addressed array can be used to determine the optical characteristics of one more candidate molecules. The invention also provides methods for making such arrays of heterocyclic compounds. In a specific embodiment, synthetic methods are provided for synthesis of triarylpyridines, particularly unsymmetric triarylpyridines. n preferred embodiments, the present invention provides novel heterocyclic fluorescent compounds having deazalumazine, cyanopyridine or pyrimidine cores. Heterocyclic fluorescent compounds of this invention are useful as dyes to label molecules such as nucleic acids, peptides and proteins, and particularly antibodies. In other embodiments, the novel heterocyclic fluorescent compounds are useful as dyes to label cellular compartments and organelles. The novel heterocyclic fluorescent compounds can also be used as sensors or indicators of specific metal ions, chemical warfare agents and pH.

专利号:US-2014328952-A1
优先权日:2011-12-21
标题:Topical compositions
发明人：FLAVIN DANA
权利人:FLAVIN DANA
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-8790720-B2
优先权日:2011-12-22
标题:Compositions and methods for treating skin
发明人：RICHARDS JEANETTE ANTHEA; DAWSON THOMAS LARRY; COMBS MARY JANE; DUEVA-KOGANOV OLGA; KOGANOV MICHAEL
权利人:PROCTER & GAMBLE
摘要:The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.