CAS: 26020-55-3; Oxetorone
该化合物是一种主要因其在制药领域应用而得到承认的合成有机化合物,被归类为非类固醇抗炎药物(NSAID),以其止痛特性而著称;氧化激素的化学结构具有有助于其生物活动的功能组别的独特安排;有机溶剂中表现出中等溶解性,这在各类化合物中是典型的,而其在水中的溶解性则有限;有机激素的操作机制涉及抑制环氧酶酶,导致原甲状腺素合成的减少,而这种合成是炎和疼痛的媒介;该化合物已经研究过其潜在的治疗作用,尽管其临床用途可能因地区和监管批准状况而有所不同;与许多药物,安全性和功效简介一样,而氧化素可能具有相关的副作用,因此需要在其应用中加以考虑.
- 英文名称Oxetorone
- 中文名称奥昔托隆
- IUPAC名称3-(12H-Benzofuro(3,2-c)(1)benzoxepin-6-yliden)-N,N-dimethylpropylamin
- 其它别名Benzofuro[3,2-c][1]benzoxepin-D6(12H),g-propylamine, N,N-dimethyl-(8CI); Benzofuro[3,2-c][1]benzoxepin, 1-propanamine deriv.; 6-(3-Dimethylaminopropylidene)benzofuro[2,3-e]-12H-benzo[b]oxepine; Oxetorone
- CAS编号26020-55-3
- MFCD编号:MFCD00864335
- EINECS号:247-411-3
- FDA UNII编号:T3XOS33TIQ
- 分子式:C21H21NO2分子量:319.4
- 产品CID: 1227786
- 同类组份化合物CAS26020-55-3 (free base); 34522-46-8 (fumarate)
- 产品分类有机原料 → 有机杂环化合物 → 苯并噁庚英
物理性质
MSDS等安全信息
合成工艺路线路线简述
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专利信息
专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
专利号:WO-2005075459-A1
优先权日:2004-02-03
标题:Synthesis of cyanoimino-benzoimidazoles
专利号:EP-1711484-A1
优先权日:2004-02-03
标 题:Synthesis of cyanoimino-benzoimidazoles
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品牌试剂参考报价(招募中)
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主要参考文献
1: Macaigne G, Boivin JF, Chayette C, Cheaib S, Deplus R. Colite lymphocytaire associée à la prise d'oxétorone [Oxetorone-associated lymphocytic colitis]. Gastroenterol Clin Biol. 2002 May;26(5):537. French. 55(2):142-146. doi: 10.1080/15563650.2016.1267358. Epub 2016 Dec 14. 58(2):166-7. French. doi: 10.2515/therapie:2003025. 61(6):548-50. French. doi: 10.2515/therapie:2006081. 16(8):560-1. doi: 10.1046/j.1468-2982.1996.1608560.x. 34(2):154-5. French. doi: 10.1016/j.gcb.2009.12.001. Epub 2010 Jan 21. 28(1):111-6. doi: 10.3109/15563659008993482. 213(1-2):35-41. French. doi: 10.1051/jbio/2019019. Epub 2019 Jul 5. 34(9):1007-10. 65(28):879-82. French.
合成参考文献
摘要:Macaigne G, Boivin JF, Chayette C, Cheaib S, Deplus R. [Oxetorone-associated lymphocytic colitis]. Gastroenterol Clin Biol. 2002 May;26(5):537.
摘要:Ducros A. [National ranking exam. N64. What could fall at the exam ]. Rev Prat. 2008 Mar 15;58(5):549–50.
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