CAS: 244221-57-6; 5-Chloro-2-Iodopyridine

相似化合物

77332-89-9 22918-03-2 258506-66-0

上下游产品

CAS号349-94-0 5-氯-2-三氟甲基吡啶 | CAS号89809-64-3 2-氰基-5-氯吡啶 | CAS号31181-89-2 5-氯吡啶-2-甲醛 | CAS号823221-95-0 5-氯-4-碘-2-(三氟甲基)吡啶 | CAS号823221-96-1 Pyridine, 3-chl...

2,5-二氯吡啶置于三甲基氯硅烷,Sodium Iodide体系中,用 Various Solvent(S) 用作溶剂,化学反应 96.0H,以52%的收率获得2-碘-5-氯吡啶
参考文献:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
标题:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
摘要:用溴三甲基硅烷加热将 2-氯吡啶转化为 2-溴吡啶,将 2-氯-6-甲基吡啶转化为 2-溴-6-甲基吡啶.2-氯吡啶和2-溴吡啶都得到相应的碘化合物.当用原位生成的碘三甲基硅烷处理时.尽管 3-和 4-氯吡啶是完全惰性的,但 2,4-二氯吡啶在 2-和 4-位同时进行卤素/卤素交换.卤素置换仅在 2-位与 2,3-二氯吡啶和 2,5-二氯吡啶发生.与作为发生卤素交换的先决条件的 N-三甲基甲硅烷基吡啶鎓盐的中间体一致,2-氟吡啶和 2-氟-6-甲基吡啶和任何 2,6-二卤代吡啶都不发生反应.最后,溴/氯和碘/氯取代也可以用 2-或 4-氯喹啉,1-氯异喹啉,2-氯嘧啶,氯吡嗪和 2,3-二氯喹喔啉作为底物来完成.[在 Scifinder (R) 上]
Doi:10.1002/1099-0690(200212)2002:24<4181::Aid-Ejoc4181>3.0.Co;2-M

专利信息

专利号:US-2008269233-A1
优先权日:2005-08-04
标 题:Piperidinoyl-Pyrrolidine and Piperidinoyl-Piperidine Compounds
发明人：ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN
权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN
摘要:The present invention relates to a class of compounds of general formula (I) n n n n n n n n n n and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R 6 , R 7 and R 10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

专利号:US-8138188-B2
优先权日:2006-02-23
标题 :Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
发明人：ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM
权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM; PFIZER
摘要:The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) n nwherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

专利号:CN-115057803-B
优先权日:2022-07-28
标 题:Synthesis method and application of S-(methyl-d3) phenyl sulfide substances

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof

专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof