CAS: 225785-54-6; 3-Methyl 5-Propyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
该化合物是一种二丙钙管阻塞剂,二丙烯丙烯丙烯酯合成衍生物,主要用于研究和制药开发,因为它的药理动力特性有所改变,与母分子相比,可能会提高溶性或生物利用率,其结构允许与L型钙管有选择地互动,使其成为研究心血管机制的候选体.丙基酯组引入了潜在的代谢稳定性,便利了实验环境中的长期活动.该化合物在针对高血压和相关血管紊乱的临床前调查中很受关注,由于对光和湿度的敏感性,通常在受控制的条件下处理.
- 英文名称3-Methyl 5-Propyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
- 中文名称尼群地平丙酯
- IUPAC名称3-Methyl 5-propyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 其它别名Nitrendipine Propyl Ester; 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-Propyl Ester; Lercanidipin Impurity 7; Lercanidipin Impurity; 3-Methyl 5-Propyl 2,6-Dimethyl-4-(3-Nitrophenyl); Nitrendipine Propyl Ester (Lercanidipine Impurity 7); 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, 3-Methyl 5-Propyl Ester; 3-Methyl 5-Propyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
- CAS编号225785-54-6
- MFCD编号:MFCD00630221
- FDA UNII编号:RE4UWZ927G
- 分子式:C19H22N2O6分子量:374.39
- 产品CID: 1163892
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
3-Amin°Crotonsaeure-propylester methyl 2-(3-nitrophenylmethylene)acetoacetate 3-nitro-benzaldehyde acetoacetic acid methyl ester合成工艺路线路线简述
📜间硝基苯甲醛置于哌啶,溶剂黄146体系中,用 乙醇 用作溶剂,化学反应 6.0H,反应生成尼群地平丙酯
参考文献:Synthesis And Antihypertensive Activity Evaluation In Spontaneously Hypertensive Rats Of Nitrendipine Analogues
标题:Synthesis And Antihypertensive Activity Evaluation In Spontaneously Hypertensive Rats Of Nitrendipine Analogues
摘要:The Antihypertensive Activity Of Nitrendipine Analogues Can Be Improved By Properly Lengthening Its Alkyl Chain In 3-Or 5-Position. Nitrendipine And Its Seven Analogues Were Synthesized,And Their Antihypertensive Activities In Spontaneously Hypertensive Rats (Shr) Were Evaluated By Ig Administration. It Was Found That 5-N-Heptyl 3-Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate [(+/-)-5] Exhibited The Strongest Antihypertensive Effect Amongst Eight Compounds. (+)-5-N-Heptyl 3-Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate [(+)-5] Was Also Prepared. Antihypertensive Activities Of (+/-)-5 And (+)-5 In Shr Were Compared. The Results Showed That (+/-)-5 And (+)-5 Had A Higher Potency Than Nitrendipine,And (+)-Isomer Was 1.79-Fold The Raceme At A Dose Of 2 Mg/kg.
Doi:10.1007/s00044-010-9477-0
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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合成参考文献
参考文献:10.1007/s00044-010-9477-0
摘要:Zhou K, Wang X, Zhao Y, Cao Y, Fu Q, Zhang S. Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of nitrendipine analogues. Medicinal Chemistry Research. 2010 Oct 28;20(8):1325–30. doi: 10.1007/s00044-010-9477-0.
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