CAS: 2243-27-8; Nonanenitrile

相似化合物

112-05-0 124-19-6 2437-25-4

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CAS号111-83-1 1-溴代正辛烷 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号124-19-6 正壬醛 | CAS号5414-21-1 5-溴戊腈 | CAS号693-04-9 正丁基氯化镁 | CAS号151-50-8 氰化钾 | CAS号2243-24-5 N-nonylidenehyd... | CAS号111-87-5 正辛醇 | CAS号10442-39-4 氰化四丁基胺 | CAS号111-88-6 1-辛硫醇 | CAS号1120-07-6 壬醯胺 | CAS号105-13-5 对甲氧基苄醇 | CAS号26438-26-6 1-nonylnaphthalene | CAS号540-08-9 9-十七酮 | CAS号112-20-9 正壬胺 | CAS号33841-61-1 2-辛基吡啶 | CAS号18277-02-6 hexadecan-8-one | CAS号478404-10-3 2,6-二溴-4,4-二辛基环...

📜壬酸置于草酰氯,三乙胺,N,N-二甲基甲酰胺,三氟乙酸酐体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 48.0H,反应生成壬基腈
参考文献:批量与流动锂取代1,3,4-恶二唑:使用流动化学开发不稳定的中间体.
标题:批量与流动锂取代1,3,4-恶二唑:使用流动化学开发不稳定的中间体.
摘要:1,3,4-恶二唑是药物化学中的常见基序,但是很少有方便的修饰方法.与以前的报道相矛盾的是,在批量和连续流动条件下,使用金属化-亲电捕集技术开发了一种快速,方便,高收率的和一般的1,3,4-恶二唑α-取代的方法,这与以前的报道相矛盾.该环系统导致环断裂.分批地,在工业上方便的温度-30oc下完成锂化,随后的捕集可得到高达91%的分离产率.在连续流动条件下,金属化在室温下进行,随后在流动中进行亲电捕集,得到定量的分离产率.尤其,
Doi:10.1002/chem.201902917

专利信息

专利号:US-4240961-A
优先权日:1979-05-29
标 题 :Synthesis of 2-piperazinones and 1,4-diaza-2-keto-cycloheptanes
发明人：LAI JOHN T
权利人:GOODRICH CO B F
摘要:Substituted 2-piperazinones are prepared by reacting a substituted 1,2-diamine with (a) an acyclic or cyclic cyanohydrin acetate, (b) a haloform, and (c) alkali metal hydroxide, in the presence of a suitable organic solvent, at ambient pressure and temperature preferably lower than about 20° C. In an analogous manner, substituted 1,4-diaza-2-keto-cycloheptanes are prepared by reacting substituted 1,3-propane-diamines. In this synthesis, referred to as 'the cyanohydrin acetate synthesis,' the reaction is accelerated with a phase transfer catalyst selected from the group consisting of a polyether, an onium salt, and a tertiary amine. This synthesis yields predominantly a 2-keto-diazacycloalkane with substituents desirably substituted on carbon atoms on either side of the N 4 atom of the diaza ring.

专利号:US-4246412-A
优先权日:1979-08-27
标 题:Synthesis of 2-keto-1,4-diazacycloalkanes with a soft ion catalyst
发明人：LAI JOHN T
权利人:GOODRICH CO B F
摘要:A phase transfer catalyzed 'soft ion synthesis' is disclosed in which the presence of a 'soft ion' generated in situ by a soft ion catalyst has a directive effect which favors the formation of a polysubstituted 2-keto-1,4-diazacycloalkane isomer having substituents on both N4-adjacent carbon atoms ('C atoms') of its diaza ring; this isomer is formed at the expense of isomers in which an N4-adjacent C atom is not substituted. Such an isomer which has substituents on each N4-adjacent C atom is generally more effective as a u-v light stabilizer than an isomer which has an unsubstituted N4-adjacent C atom, and therefore the former is more desirable. A liquid phase reaction of an acyclic 1,2-diamine with a monoketone or monoaldehyde in the presence of a phase transfer catalyst, a haloform and alkali is disclosed, in which reaction a soft ion catalyst which generates a soft ion selected from the group consisting of cyanide, iodide and thiocyanate, has a directive effect on the reaction so as to produce more isomer with substituents on each N4-adjacent C atom than would be formed, under identical conditions but without the presence of the soft ion. The directive effect of the soft ion appears to enhance any directive effect that a particular phase transfer catalyst may exhibit.

专利号:US-4711957-A
优先权日:1979-07-13
标题 :Synthesis of 2-keto-1,4-diazacycloalkanes
发明人：LAI JOHN T
权利人:GOODRICH CO B F
摘要:The disclosure deals with novel synthesis involving (a) hydrogenation of a cis-3,3-dialkyl-3,4-dihydroquinoxaline-2-one in the presence of a suitable hydrogenation catalyst, at elevated temperature and pressure, to yield a cis-3,3-dialkyl decahydroquinoxaline-2-one; (b) reaction of trans-1,2-diaminocyclohexane with acetone cyanohydrin in the presence of water to yield trans-3,3-dimethyl-decahydroquinoxaline-2-one; and (c) a reaction of 1,2-diamine with a saturated acyclic or cyclic monoketone or aldehyde and a holoform, in the presence of (i) a phase transfer catalyst (ii) an organic solvent, and (iii) solid or aqueous alkali to yield 2-keto-1,4-diazacycloalkanes. Such compounds exhibit exceptional UV light stabilizing property.

专利号:EP-0468457-B1
优先权日:1990-07-24
标题 :Novel substituted piperidines and their use as inhibitors of cholesterol synthesis
发明人：MCCARTHY JAMES R; BARNEY CHARLOTTE L; WANNAMAKER MARION W
权利人:MERRELL DOW PHARMA
摘要:The present invention relates to a group of compounds which are novel substituted piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.

专利号:US-2023219881-A1
优先权日:2022-01-11
标题 :Synthesis of Spermidine, Spermine, and Free Bases Thereof
发明人：TITLOW MATTHEW; GU XINGLONG
权利人:COMPOUND SOLUTIONS INC; SHAOXING KING YEAR BIOCHEMICAL CO LTD
摘要:A simplified synthetic process for production of spermine and spermidine are presented that can provide spermine and spermidine in free base or salt form. Advantageously, the synthetic procedure is safe, simple, and environmentally friendly, while at the same time also being cost-effective.

专利号:US-4219684-A
优先权日:1979-04-02
标 题 :Synthesis of alcohols by hydroformylation with nitrile promoter
发明人：IMAI TAMOTSU
权利人:UOP INC
摘要:Alcohols may be synthesized by reacting an olefinic compound, carbon monoxide and hydrogen in the presence of a Group VIII organometallic complex catalyst at reaction conditions which include a temperature in the range of from about 50° to about 250° C. and a pressure in the range of from about 10 to about 300 atmospheres. In addition, the reaction is also effected in the presence of a promoter compound comprising a nitrile.