专利号:US-7897718-B2 优先权日:2005-05-19 标题:Acrylated semi-crystalline hyperbranched polyurethane oligomer and preparation method thereof 发明人:CHANG CHI-KANG; CHEN CHIN-YUAN; SHI WEN-FANG; LIANG HONG-BO 权利人:ETERNAL CHEMICAL CO LTD 摘要:The present invention relates to an acrylated semi-crystalline hyperbranched polyurethane oligomer and a preparation method thereof, which is characterized in that on the basis of the synthesis of hyperbranched polyurethane oligomer, it adopts a two-step process to make modifications to form a methacrylic and/or acrylic double bond and a long carbon chain with a carbon atom number higher than 10 or a benzene ring or a naphthalene ring at the terminals. The obtained oligomer has a lower melting point and a higher glass transition temperature and can be cured by means of radiation, and the curing rate is high enough to effectively improve production efficiency and save energy to form a cured film having a higher hardness and excellent thermal stability. The raw materials used in the method of the invention are easily obtained, and the method is suitable for large-scale production in industry.
专利号:US-7468130-B2 优先权日:2005-02-15 标题 :Organosilanes and substrates covalently bonded with same and methods for synthesis and use same 发明人:LIU XIAODONG; POHL CHRISTOPHER A 权利人:DIONEX CORP 摘要:The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
专利号:DE-1921012-A1 优先权日:1968-04-29 标题:Process for the synthesis of antibacterial substances
专利号:CN-110536748-B 优先权日:2017-05-08 标 题:Highly efficient synthesis of Z-macrocycles using a sterically retentive ruthenium-based metathesis catalyst
专利号:CN-103819364-B 优先权日:2014-01-24 标题:One-pot Synthesis of N-hydrocarbonyl Lactam Derivatives
专利号:RU-2081870-C1 优先权日:1991-04-12 标 题:Diazepinone derivatives, methods of their synthesis and pharmaceutical composition
参考标题:Studies On Hypolipidemic Agents. Ii Synthesis Of 1-Arenesulfonyloxy-2-Alkanone Derivatives As Potent Esterase Inhibitors And Hypolipidemic Agents. 作者:Kazuo Ogawa,Tadafumi Terada,Yoshiyuki Muranaka,Toshihiro Hamakawa,Sadao Hashimoto,Setsuro Fujii 摘要:Many 2-Oxoalkyl Arenesulfonate Derivatives Having Straight Or Branched Alkyl Chains Of Different Lengths, 2-Oxoalkyl Bis-Arenesulfonate Derivatives, And Alkyl Arenesulfonate Derivatives Having A Ketal Moiety At The 2-Position On The Alkyl Chain Were Synthesized, And Their Esterase-Inhibitory Activities, As Well As Hypolipidemic Activities, Were Evaluated.Among These Compounds, 1-(2, 4, 6-Trimethylbenzenesulfonyloxy)-2-Dodecanone (Iii-1U), And 1-(2, 3, 4, 6-Tetramethylbenzenesulfonyloxy)-2-Hexanone (Iii-1W), -2-Octanone (Iii-1X) And -2-Decanone (Iii-1Y) Exhibited Potent Esterase-Inhibitory Activities (Ic50=3X10-10, 2X10-10, 2X10<-10> And 3X<-11>M, Respectively). However, The Sulfonate (Xv) Having A Ketal Moiety On The Alkyl Chain And The Bis-Sulfonate (Xvi) Exhibited Low Inhibitory Activities Toward Esterase In Comparison With Iii And Xii. Most Of The Compounds Iii And Some Of The Compounds Xii Exhibited Potent Hypolipidemic Activities Corresponding To More Than 50% Lipid-Lowering Effect (Plasma Triglyceride And Cholesterol Ester) In Vivo. The Structure-Activity Relatioinships Of These Compounds Are Discussed.
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003). 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003). 摘要:Burton, J. W., Science of Synthesis, (2002) 4, 63. 摘要:Whitehead, A.; Sieck, S. R.; Mukherjee, S.; Hanson, P. R., Science of Synthesis, (2005) 21, 923. 摘要:Harcken, C., Science of Synthesis, (2007) 25, 70.