CAS: 122497-20-5; Dimethyl 2-(2-(2-Aminopurine-9-yl)Ethyl)Malonate

上下游产品

2-Amino-9-(3,3-Dicarbomethoxycyclopropyl)Purine 225922-26-9
2-Amino-6-Chloro-9-(3,3-Dicarbomethoxy-2,2-Dichlorocyclopropyl)Purine 225922-05-4

📜5-[2-(2-Aminopurin-9-yl)Ethyl]-2,2-Dimethyl-1,3-Dioxacyclohexane-4,6-Dione置于盐酸,甲醇体系中,化学反应 16.0H,以82%的收率获得泛昔洛韦杂质12
参考文献:A Direct Approach To The Synthesis Of Famciclovir And Penciclovir
标题:A Direct Approach To The Synthesis Of Famciclovir And Penciclovir
摘要:Reaction Of 2-Amino-6-Chloropurine With Triethyl 3-Bromopropane-1,1,1-Tricarboxylate Followed By Decarbethoxylation/transesterification Of The Unpurified Product Was The Key Sequence In Synthesising Both The Anti-Herpesvirus Agent Penciclovir And Its Oral Form Famciclovir In Three Isolated Steps.
Doi:10.1080/07328319608002029