CAS: 1118-89-4; H-Glu(Oet)-Oet.Hcl

相似化合物

1001-19-0 138-15-8 1499-55-4

上下游产品

CAS号64-17-5 乙醇 | CAS号56-86-0 L-谷氨酸 | CAS号3929-61-1 H-Glu-Glu-OH | CAS号80576-83-6 依达曲沙 | CAS号7149-65-7 L-焦谷氨酸乙酯 | CAS号103003-96-9 5,10-methylene-... | CAS号157034-04-3 diethyl (2S)-2-... | CAS号112889-02-8 N-(5-甲氨基-2-噻吩甲酰... | CAS号146943-43-3 N-(4-(2-(2-氨基-4... | CAS号145080-95-1 (S)-(-)-2-异氰酰基戊二酸二乙酯 | CAS号112887-68-0 雷替曲塞 | CAS号132463-02-6 N-[5-[N-[(3,4-二...

L-谷氨酸 反应生成L-谷氨酸二乙酯盐酸盐
参考文献:Akabori,Chemische Berichte,1933,Vol. 66,P. 151,158
标题:Akabori,Chemische Berichte,1933,Vol. 66,P. 151,158

专利信息

专利号:US-5633373-A
优先权日:1989-07-07
标 题 :Enantioselective synthesis of antifolates
发明人：BARNETT CHARLES J; WILSON THOMAS M
权利人:LILLY CO ELI
摘要:A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

专利号:WO-2013164856-A1
优先权日:2012-05-04
标题 :A process for preparing intermediates of 10-propargyl-10-deazaaminopterin (pralatrexate) synthesis and the intermediates thereof
发明人：ALLA RAMA RAO VENKATA; RAMARAO CHANDRASHEKAR; MICHEL PATRICK THOMAS; NITLIKAR LAKSHMIKANT HANUMANTHRAO; KALAM BHUPATHI REDDY; DUDUKA RAMPRASAD
权利人:AVRA LAB PRIVATE LTD; ALLA RAMA RAO VENKATA; RAMARAO CHANDRASHEKAR; MICHEL PATRICK THOMAS; NITLIKAR LAKSHMIKANT HANUMANTHRAO; KALAM BHUPATHI REDDY; DUDUKA RAMPRASAD
摘要:A process for preparation of 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid and other key intermediates in synthesis of 10-propargyl-10-deazaaminopterin (Pralatrexate) and the intermediates thereof. The 10-propargyl-10-deazaaminopterin (Pralatrexate) is obtained by peptide formation and ester hydrolysis of the intermediate compound 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid by methods known in the art.

专利号:US-8981090-B2
优先权日:2010-07-22
标 题:Process for the synthesis of pemetrexed disodium salt
发明人：CIAMBECCHINI UMBERTO; TURCHETTA STEFANO; ZENONI MAURIZIO; DE FERRA LORENZO; BRANDI PAOLO
权利人:CIAMBECCHINI UMBERTO; TURCHETTA STEFANO; ZENONI MAURIZIO; DE FERRA LORENZO; BRANDI PAOLO; CHEMI SPA
摘要:The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 n nby purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solventn n ncharacterized in that the mixture is subjected to the following steps:n a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2.

专利号:US-5698556-A
优先权日:1995-06-07
标题 :Methotrexate analogs and methods of using same
发明人：CHAN CARCY L
摘要:The present invention provides methotrexate analogs having the formula: +TR wherein R is methyl or hydro, X is halo or hydro, and D1 is -NR1R2 wherein either both R1 and R2 are hydrogen, or one is hydrogen and the other is C1-C5 alkyl, C1-C5 haloalkyl, cyano C1-C5 alkyl, C1-C5 hydroxyalkyl, alkoxyalkyl wherein the alkoxy and the alkyl have 1-5 carbon atoms, carboxy C1-C5 alkyl, phenyl, C1-C5 alkyl phenyl, C(=O)R' wherein R' is hydrogen, C1-C5 alkyl, phenyl, or C1-C5 alkyl phenyl, C(=O)OR'' wherein R'' is hydrogen, C1-C5 alkyl, phenyl, or C1-C5 alkyl phenyl, amino, C(=NH)NH2, C(=O)NH2, or C(=S)NH2, and structurally related derivatives, as well as pharmaceutical compositions comprising such MTX analogs, methods of synthesis of the MTX analogs, and use of the MTX analogs in modulating cellular functions, or in treating cancer and other diseases or disorders capable of being treated using MTX.

专利号:US-5981748-A
优先权日:1995-06-07
标题:Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates
发明人：VARNEY MICHAEL D; ROMINES WILLIAM H; PALMER CYNTHIA L
权利人:AGOURON PHARMA
摘要:The invention relates to methods of making compounds of the formula VII ##STR1## and their enantiomers, where Ar is a substituted or unsubstituted five- or six-membered aromatic group and B is either an amino acid linked through the amino portion to form an amide or a C 1 -C 6 alcohol linked through the alcohol portion to form an ester. These compounds are advantageously employed as intermediates to prepare optically pure compounds that are active GARFT inhibitors. In one method, a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## where X is a halogen.

专利号:US-2012282652-A1
优先权日:2011-02-28
标题 :Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties
发明人：GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU
权利人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU; POLITECHNIC INST UNIV NEW YORK
摘要:A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide.