CAS: 106261-49-8; 4-[(4-Methylpiperazin-1-yl)Methyl]Benzoic Acid Dihydrochloride

相似化合物

106261-48-7 479353-63-4 125743-63-7

对氯甲基苯甲酸,N-甲基哌嗪置于乙醚,Sodium Hydroxide,Ice Water,Hemihydrate体系中,用 乙醇 用作溶剂,化学反应 16.03H,以were Obtained 9.4 G (35%) Of Pure 4-(4-Methylpiperazinomethyl)Benzoic Acid Dihydrochloride (9) As The Hemihydrate,M.P. 310°-312oc的收率获得4-[(4-甲基哌嗪-1-基)甲基]苯甲酸二盐酸盐
参考文献:Methods And Compositions Related To Wrapping Of Dehydrons
标题:Methods And Compositions Related To Wrapping Of Dehydrons
摘要:该应用程序描述了一种新颖的药物发现和基于药物成像/检测的技术:包裹技术.该技术基于可溶性蛋白质结构中的已确定的奇点.与基于标准结构考虑的药物设计方法相比,蛋白质的包装,或更精确地说,其脱水模式,可以用作选择性过滤器,设计小分子抑制剂.此处描述的包裹技术是一种新形式的理性药物设计,用于避免药物治疗中的副作用,并增强药物对癌症基因组的抑制作用.

专利信息

专利号:WO-2013035102-A1
优先权日:2011-09-05
标 题 :Processes for the preparation of imatinib base and intermediates thereof
发明人：KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.

专利号:US-2023065387-A1
优先权日:2019-10-14
标题:Synthesis of tyrosine kinase inhibitors

专利号:US-2011097268-A1
优先权日:2006-08-23
标 题 :Radiohaloimatinibs and methods of their synthesis and use in pet imaging of cancers
发明人：BORNMANN WILLIAM; ALAUDDIN MIAN; GELOVANI JURI; GHOSH PRADIP; GUO LIWEI; HAN DONGMEI; MAXWELL DAVID; MUKHOPADHYAY UDAY; PENG ZHENGHONG; SHAVRIN ALEKSANDR; YING YUNMING
权利人:UNIV TEXAS
摘要:We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.

专利号:AU-2008214679-A1
优先权日:2007-02-13
标题 :Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors

专利号:US-2010121063-A1
优先权日:2007-02-13
标题:Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors

专利号:CA-2970628-A1
优先权日:2007-02-13
标题:Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors