CAS: 1041-01-6; (S)-2-Amino-3-(4-(4-Hydroxyphenoxy)-3,5-Diiodophenyl)Propanoic Acid

相似化合物

534-51-0 1041-01-6 203585-45-9

上下游产品

CAS号178877-78-6 B°C-3,5-二碘-L-甲状腺素 | CAS号54337-43-8 1-oxaspiro[2.5]... | CAS号300-39-0 3,5-二碘-L-酪氨酸 | CAS号623-05-2 对羟基苯甲醇 | CAS号60-18-4 L-酪氨酸 | CAS号1080-06-4 L-酪氨酸甲酯 | CAS号4326-36-7 B°C-L-酪氨酸甲酯 | CAS号128781-80-6 (S)-2-((叔丁氧基羰基)... | CAS号51-48-9 左旋甲状腺素 | CAS号203585-45-9 o-(4-羟基苯基)-3,5-... | CAS号1596-67-4 L-甲状腺氨酸 | CAS号6893-02-3 三碘甲状腺原氨酸

3,5-二碘-L-酪氨酸置于copper(II) Perchlorate Hexahydrate,氢碘酸,溶剂黄146,Sodium Hydroxide体系中,用 二氯甲烷,水 用作溶剂,化学反应 8.67H,反应生成3,5-二碘-L-甲状腺素
参考文献:一种左甲状腺素钠的制备方法
标题:一种左甲状腺素钠的制备方法
摘要:本发明属于医药合成领域,公开了一种左甲状腺素钠的制备方法,步骤如下:1)以3,5‑二碘‑l‑酪氨酸为原料首先在氨基上引入乙酰基保护制备n‑乙酰基‑l‑酪氨酸;2)然后在二氯亚砜作用下制备得到n‑乙酰基‑3,5‑二碘‑l‑酪氨酸乙酯;3)再经过铜催化发生chan‑lam反应制备n‑乙酰基‑o‑(4‑甲氧基苯基)‑3,5‑二碘‑l‑酪氨酸乙酯;4)在强酸性条件下脱去保护基得到o‑(4‑羟基苯基)‑3,5‑二碘‑l‑酪氨酸;5)再与碘反应并在氢氧化钠作用下制备o‑(4‑羟基‑3,5‑二碘苯基)‑3,5‑二碘‑l‑酪氨酸二钠盐;6)最后经过冰醋酸调节ph制备得到左甲状腺素钠.本发明对关键的chan‑lam反应及其他反应步骤进行了优化,能够极大地缩短反应时间,提高反应收率,且工艺简单,操作方便,适合工业化生产.

专利信息

专利号:US-8759572-B2
优先权日:2009-12-18
标 题:Process for the preparation of thyroid hormones and salts thereof
发明人：VISCARDI CARLO FELICE; CAPPELLETTI ENRICO; GALIMBERTI LAURA; GAZZETTO SONIA; SINI LOREDANA
权利人:VISCARDI CARLO FELICE; CAPPELLETTI ENRICO; GALIMBERTI LAURA; GAZZETTO SONIA; SINI LOREDANA; BRACCO IMAGING SPA
摘要:The present invention generally refers to a process for the preparation of L-thyroxine derivatives. More in particular, the present invention relates to a iodination reaction of an aromatic derivative with an appropriate iodinating agent, so to afford the related iodinated compound as disodium salt, which may represent a useful intermediate for the synthesis of the L-thyroxine mono-sodium salt, and the free form thereof.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.