专利号:US-7846656-B2 优先权日:2001-10-16 标 题:Composition for polymerizing immobilization of biological molecules and method for producing said composition 发明人:MIRZABEKOV ANDREI DARIEVICH; RUBINA ALLA JURIEVNA; PANKOV SERGEI VASILIEVICH 权利人:INST MOLEKULYARNOI BIOLOG IM V 摘要:The invention refers to the field of molecular biology and bio-organic chemistry and deals with a composition for immobilization in polymer carriers of oligonucleotides, proteins, nucleic acids or any other molecules, which structure comprises active groups, including amino- or sulfhydryl groups, as well as a method for immobilization of various molecules including oligonucleotides, proteins, nucleic acids or any other molecules which structure comprises active groups, including amino- or sulfhydryl groups, consisting of a porous polymer being obtained on the basis of the composition claimed under conditions of addition or substitution reaction (radical, nucleophilic, or electrophilic nature, etc.) during synthesis of polymer by photo- and chemical initiated polymerization. n The composition claimed, as well as the method of immobilization of molecules in a polymer carrier using these compositions, may be used in various applications including microchips manufacturing that use is made of molecular biology on DNA sequencing and mapping, on detection of mutations and a whole range of medical applications.
专利号:US-10968173-B2 优先权日:2016-07-07 标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization 发明人:COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN 权利人:UNIV IOWA STATE RES FOUND INC 摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.
专利号:US-2002001821-A1 优先权日:1994-02-10 标 题:Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
专利号:US-2011104052-A1 优先权日:2007-12-03 标 题 :Methods of synthesis and use of chemospheres 发明人:BARNETT BRADLEY POWERS; GESCHWIND JEFFREY 权利人:UNIV JOHNS HOPKINS 摘要:The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.
专利号:US-6127154-A 优先权日:1994-02-10 标题 :Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof 发明人:MOSBACH KLAUS; CORMACK PETER A G; RAMSTROEM OLOF; HAUPT KARSTEN 摘要:Compounds which possess a complementary structure to a desired molecule, such as a biomolecule, in particular polymeric or oligomeric compounds, which are useful as in vivo or in vitro diagnostic and therapeutic agents are provided. Also, various methods for producing such compounds are provided. These polymeric or oligomeric compounds are useful in particular as antimicrobial agents, receptor, hormone or enzyme agonists and antagonists.
专利号:US-5994110-A 优先权日:1995-02-10 标 题 :Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof 发明人:MOSBACH KLAUS; CORMACK PETER A G; RAMSTROM OLOF; HAUPT KARSTEN 摘要:Compounds which possess a complementary structure to a desired molecule, such as a biomolecule, in particular polymeric or oligomeric compounds, which are useful as in vivo or in vitro diagnostic and therapeutic agents are provided. Also, various methods for producing such compounds are provided. These polymeric or oligomeric compounds are useful in particular as antimicrobial agents, receptor, hormone or enzyme agonists and antagonists.
参考文献:10.1007/978-3-031-67368-9_8 摘要:Sehit E, Bräuer B, Lieberzeit P, Altintas Z. Recent Trends in MIP-Based Virus Sensors. 2024 Nov 07. In: Springer Series on Polymer and Composite Materials.