CAS: 86060-90-4; Fmoc-Pro-Opfp

该化合物是一个化学化合物,其结构复杂,包括一个阳性环和多种功能组,其特性包括:氟基甲基组的存在有助于其芳香特性,而五氟基苯会加强其电子提取特性,有可能影响其再活性和溶解性.由于庞大的芳香系统,该化合物可能会表现出明显的疏滑性,这可能会影响其生物活动以及与其他分子的相互作用.此外,两个碳红色组的存在表明氢结合和电离相互作用的潜力,这可能在其溶解极溶剂中发挥作用.

结构式图片

相似化合物

86060-94-8 125281-38-1 132990-14-8

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

2,3,4,5,6-pentafluorophenol Fm°C-Pro-OH (S)-N-(fluoren-9-ylmethoxycarbonyl)prolyl chloride (9-fluorenyl)methyl pentafluorophenyl carbonatePro-Thr-Tyr-Pro-Thr-α-N-(°Ctyloxybenzoyl)-Orn (S)-2-[(S)-1-((3R,4S)-1-Methoxycarbonylmethyl-2-oxo-4-phenyl-azetidin-3-yl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester N-(9H-fluoren-9-ylmethoxycarbonyl)-L-prolyl-L-prolylglycine benzyl ester N-9-fuorenylmethoxycarbonyl-(2S)-prolyl-(2S,4S)-4-methylprolyl-glycine benzyl ester

合成工艺路线路线简述

  • 771-61-9 + 103321-52-4 = 86060-90-4
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water
    标题:Synthesis Of Pentafluorophenyl,2,4,5-Trichlorophenyl And Pentachlorophenyl Esters Of Fmoc-Amino Acids Using Fmoc-Amino Acid Chlorides As Intermediates
    作者:Babu,Vommina V. Suresh; Ananda,Kuppanna; Mathad,Raveendra I.
    参考文献:Letters In Peptide Science 日期:2001 卷标:7(4) 页码:239-242]

    771-61-9 + 71989-31-6 = 86060-90-4
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Ethyl Acetate; 2 H,0 °C
    标题:Pentafluorophenol
    作者:Jones,Keith; Deamicis,Carl
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2009 卷标:1 页码:1-9]

    771-61-9 + 71989-31-6 = 86060-90-4
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Ethyl Acetate
    标题:9-Fluorenylmethyl Pentafluorophenyl Carbonate As A Useful Reagent For The Preparation Of N-[(9-Fluorenylmethoxy)Carbonyl] Amino Acids And Their Pentafluorophenyl Esters
    作者:Schon,Istvan; Kisfaludy,Lajos
    参考文献:Synthesis 日期:1986 卷标:(4) 页码:303-5]

    771-61-9 + 71989-31-6 = 86060-90-4
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane1.2 Reagents: Pyridine Solvents: Tetrahydrofuran
    标题:A New Facile One-Pot Preparation Of Pentafluorophenyl And 3,4-Dihydro-4-Oxo-1,2,3-Benzotriazine-3-Yl Esters Of Fmoc Amino Acids
    作者:Jakobsen,Mogens Havsteen; Buchardt,Ole; Engdahl,Tom; Holm,Arne
    参考文献:Tetrahedron Letters 日期:1991 卷标:32(43) 页码:6199-202
📜9-芴甲基五氟苯基碳酸酯置于碳酸氢钠,N,N'-二环己基碳二亚胺体系中,用 水,乙酸乙酯,丙酮 作为反应溶剂,化学反应 2.0H,反应生成 Fmoc-L-脯氨酸五氟苯酯
参考文献:Schoen,Istvan; Kisfaludy,Lajos,Synthesis,1986,# 4,P. 303-305
标题:Schoen,Istvan; Kisfaludy,Lajos,Synthesis,1986,# 4,P. 303-305

海关参考信息

专利信息


专利号:US-5286789-A
优先权日:1989-05-26
标题:Solid phase multiple peptide synthesis
发明人：OKRONGLY DAVID; CLARK BRIAN R; SPESARD JACK
权利人:APPLIED IMMUNESCIENCES
摘要:Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.

专利号:EP-0400920-B1
优先权日:1989-05-26
标 题 :Solid phase multiple peptide synthesis
发明人：OKRONGLY DAVID; CLARK BRIAN R; SPESARD JACK
权利人:APPLIED IMMUNESCIENCES
摘要:Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.

专利号:EP-0604552-A4
优先权日:1991-09-18
标 题:PROCESS FOR THE SYNTHESIS OF VARIOUS COLLECTIONS OF OLIGOMERS.

专利号:EP-0708751-A1
优先权日:1993-07-16
标题:Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses

专利号:EP-0604552-A1
优先权日:1991-09-18
标 题 :PROCESS FOR THE SYNTHESIS OF VARIOUS COLLECTIONS OF OLIGOMERS.

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Efficient Solid-Phase Synthesis Of Peptide-Based Phosphine Ligands: Towards Combinatorial Libraries Of Selective Transition Metal Catalysts
作者:Christian A. Christensen,Morten Meldal |发布日期:2005.7.4
摘要:Tedious Protection/deprotection Of The Phosphine Moieties During The Synthesis Of The Ligands. The Extensive Use Of Commercial Building Blocks And Standard Spps Makes This Methodology Well Suited For The Generation Of Solid-Phase Combinatorial Libraries Of Novel Ligands. Furthermore, It Is Possible To Generate Several Different Phosphine Ligand Libraries For Every Peptide Scaffold Library Synthesised, By

合成参考文献


参考文献:10.1385/0-89603-392-9:65
摘要:Cabilly S, Meldal M. Intramolecular Fluorescence-Quenched Substrate Libraries. 1997 Dec 23. In: Combinatorial Peptide Library Protocols. : Humana Press; 1997 Dec 23.
参考文献:10.1007/bf02443584|10.1023/a:1008934125453
摘要:Gopi HN, Suresh Babu VV. Convenient and simple homologation of Nα-urethane protected α-amino acids to their β-homologues with concomitant pentafluorophenyl ester formation. International Journal of Peptide Research and Therapeutics. 2000 May;7(3):165–9. doi: 10.1023/a:1008934125453.
参考文献:10.1385/1-59259-666-5:443
摘要:Lo BKC, Reineke U. Antibody Epitope Mapping Using Arrays of Synthetic Peptides. 2003 Dec 05. In: Antibody Engineering. : Humana Press; 2003 Dec 05.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知