CAS: 86-88-4; Antu
该化合物是白色的,白色的,在有机溶剂中溶解但水溶性有限的晶状固体.其作用方式是细胞呼吸中断,可能导致鼠类呼吸衰竭.由于其毒性,ANTU被归类为一种危险物质,在处理时必须采取适当的安全措施.环境持久性和潜在生物累积性也是与使用该物质有关的问题,因此需要在虫害控制应用中认真考虑.监管机构经常监测其使用,以减轻非目标物种和人类健康的风险.
- ⚠️危险化学品目录(2015年版) 急性毒性-经口,类别2*
- 英文名称Antu
- 中文名称安妥
- IUPAC名称1-(1-Naphthyl)-2-thiourea
- 其它别名1-(1-naphthyl)-2-thiourea; 1-(1-naphthyl)thiourea; 1-naftil-tiourea
- CAS编号86-88-4
- MFCD编号:MFCD00041824
- EINECS号:201-706-3
- 分子式:C11H10N2S分子量:202.28
- 产品CID: 1872408
- 产品分类原料药 → 其它化学药 → 卫生防疫用药
物理性质
- 熔点193 °C
- 沸点377.6 °C at 760 mmHg
- 闪点182.1 °C
- 密度1.333 g/cm3
- pKa:13.12±0.70(预测)
- PSA:70.14
- LogP:3.2686
- 折射率1.794
- 蒸汽压1.1X10-6 mm Hg at 25 °C (est)
- 溶解性4.3 And 86 G/l In Acetone And Triethylene Glycol, Respectively (Windholz Et Al., 1983)
- 敏感性ANTU is incompatible with the following: Strong oxidizers, silver nitrate (NIOSH, 2024). | An organosulfide and an amide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
- 外观形态灰色至米棕色晶体或结晶粉末
- 储存条件防毒区域
- 产品应用作灭鼠药.
- 性质描述从醇中得白色棱状体结晶.熔点198°C.25°C时在水中的溶解度为0.06g/100ml,在丙醇中的溶解度为2.43g/100ml,颇易溶于热乙醇.无臭,味苦,剧毒.
MSDS等安全信息
欧盟法规
统一分类与标签压力设备指令-第1组危险流体ECHA物质工作场所安全标识要求ECHA物质食品接触材料-禁用CMR物质C&L通报REACH预注册废弃物危险特性清单上下游产品
CAS号4921-84-0 N-((1-naphthale... | CAS号551-06-4 1-萘异硫氰酸酯 | CAS号134-32-7 1-萘胺 | CAS号552-46-5 1-萘胺盐酸盐 | CAS号532-55-8 苯甲酰基异硫氰酸酯 | CAS号333-20-0 硫氰酸钾 | CAS号109967-34-2 Naphtho[1,2-d]t... | CAS号551-06-4 1-萘异硫氰酸酯 | CAS号238432-83-2 1-naphthalen-1-... | CAS号84038-90-4 9-Methyl-11H-na... | CAS号63512-54-9 1-Amino-2-napht... | CAS号40172-65-4 萘并(1,2-d)噻唑-2-胺 | CAS号398996-75-3 2-(naphthalen-1...合成工艺路线路线简述
📜1-萘异硫氰酸酯置于ammonium Hydroxide体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 49.0H,以95%的收率获得产物安妥
参考文献:基于多糖的手性固定相上的n-芳基-硫脲基烷基膦酸酯和硫代脲二(烷基膦酸酯)的高效液相色谱对映体分离.
标题:基于多糖的手性固定相上的n-芳基-硫脲基烷基膦酸酯和硫代脲二(烷基膦酸酯)的高效液相色谱对映体分离.
摘要:代表性的o,O-二苯基-N-芳硫脲基烷基膦酸酯,(+/-)-Ptc-Val P(oph)2和(+/-)-Ptc-Leu P(oph)2和硫代脲基二(异丁基膦酸酯)的首次成功对映分离tcm [Val P(oph)2] 2的分析和半制备规模是通过使用基于多糖的手性固定相(cp)的高效液相色谱实现的.使用相应醛,N-芳硫脲和亚磷酸三苯酯的改性三组分缩合得到atc‐aa P(oph)2,而tcm [val P(oph)2] 2通过醛,硫脲和亚磷酸三苯酯的缩合反应.制备的外消旋(+/-)-Atc-Aa P(oph)2 [(+/-)-Ptc-Val P(oph)2,(+/-)-Ptc-Leu P(oph)2,(+/-)-Ptc-Pgly P(oph)2和(+/-)-Ntc-Pgly P(oph)2]和外消旋(+/-)-Tcm [aa P(oph)2] 2 [(+/-)-Tcm [nva P(oph)2] 2&(+/-)-Tcm [val
DOI:10.1002/chir.22794
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主要参考文献
1: Sipahi E, Ustün H, Niyazi Ayoglu F. Acute effects of pentobarbital, thiopental and urethane on lung oedema induced by alpha-naphthythiourea (ANTU). Pharmacol Res. 2002 Mar;45(3):235-9.
4: Day BJ, Carlson GP, DeNicola DB. gamma-Glutamyltranspeptidase in rat bronchoalveolar lavage fluid as a probe of 4-ipomeanol and alpha-naphthylthiourea-induced pneumotoxicity. J Pharmacol Methods. 1990 Aug;24(1):1-8. doi: 10.1152/ajplung.00330.2009. Epub 2010 Mar 12.
10: Boyd MR, Burka LT, Wilson BJ, Sastry BV. Development of tolerance to the pulmonary toxin, 4-ipomeanol. Toxicology. 1981;19(2):85-100. Review.
合成参考文献
参考DOI号:10.1021/acs.cgd.7b01180
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