CAS: 65287-34-5; 2-Chloropyridine-4-Carbonylchloride

该化合物是一种多用途有机中间体,主要用于制药和农用化学合成.这种环环环化合物具有反应性丙烯基化合物,能够有效地衍生成胺化物,酯类和其他功能化衍生物.其氯化核具有独特的电子特性,便于在复杂的分子框架中作出选择性反应.该化合物在受控条件下的高度纯度和稳定性使其适合在药用化学中精确应用,特别是在开发活性药物成分(APIs)方面.妥善处理由于其湿度敏感度和反应性,至关重要.它作为建造生物活性分子的关键建筑块,有可能用于药物发现和作物保护.

英文名称2-Chloropyridine-4-Carbonylchloride
中文名称2-氯吡啶-4-酰氯
IUPAC名称2-chloroisonicotinoyl chloride
其它别名2-Chloro-Isonicotinoyl Chloride; 2-Chloropyridine-4-Carbonyl Chloride; Buttpark 43\57-04; 4-Pyridinecarbonyl Chloride, 2-Chloro- (9Ci); 2-Chloropyridine-4-Carbonyl Chloride, 95+%; 2-Chloropyridine-4-Carbonyl Chloride ,; 2-Chloro-4-Pyridinecarbonyl Chloride
CAS编号65287-34-5
MFCD编号:MFCD00204232
EINECS号:624-963-7
分子式:C6H3Cl2NO
分子量:176.0
产品CID: 1635384
产品分类医药中间体 → 吡啶类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: NPRZWOJTSGFSBF-UHFFFAOYSA-N
InChI=1S/C6H3Cl2NO/c7-5-3-4(6(8)10)1-2-9-5/h1-3H…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS06 & GHS05;
注释: Skull and crossbones & Corrosion
危险类别急性毒性类别3(经口)
皮肤腐蚀类别1B
严重眼损伤类别1
警示词Danger(危险)
危险描述H301 |吞咽会中毒.
H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
防范说明P280-P305+P351+P338-P310
危险等级IRRITANT
UN编号3265
危险品标志C
风险等级Corrosive/Store under nitrogen
安全声明26-36/37/39-8-45-30-23
危险类别码34-29-14-25
WGK Germany3

欧盟法规

C&L通报

上下游产品

2-chloroisonicotinic acid, Isonicotinic acid N-oxide 2,6-dichloropyridine-4-carboxylic acid 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine 2-chloro-4-pyridine carboxamide pyrrolidine-2-carboxylic acidN-(2-chloropyridin-4-yl)carbonylpyrrolidine-2-carboxylic acid (2-chloropyridin-4-yl)methanol 2-chloro-N-isopropylisonicotinamide

合成工艺路线路线简述

合成目标产物 2-Chloropyridine-4-Carbonyl Chloride 主要起始原料 2-Chloro-4-Pyridinecarboxylic Acid
(文献来源)合成步骤主要原料 2-Chloro-4-Pyridinecarboxylic Acid

异烟酸-N-氧化物置于氯化亚砜,三氯氧磷体系中,化学反应 7.0H,反应生成 2-氯吡啶-4-甲酰氯
参考文献:Vinylogous Carbinolamine Tumor Inhibitors. 24. Synthesis,Chemistry,And Antineoplastic Activity Of .Alpha.-Halopyridinium Salts: Potential Pyridone Prodrugs Of Acylated Vinylogous Carbinolamine Tumor Inhibitors.
标题:Vinylogous Carbinolamine Tumor Inhibitors. 24. Synthesis,Chemistry,And Antineoplastic Activity Of .Alpha.-Halopyridinium Salts: Potential Pyridone Prodrugs Of Acylated Vinylogous Carbinolamine Tumor Inhibitors.
摘要:A Series Of 4-And 5-[2,3-Dihydro-6,7-Bis[[(N-Alkylcarbamoyl)Oxy]Methyl]-1H-Pyrrol Izin-5-Yl]-2-Halopyridinium Iodides Were Synthesized. The Rates Of Hydrolysis Of The Alpha-Halopyridinium Salts To The Corresponding Pyridones,And The Reactivities Of The Carbamate Moieties Were Studied As A Function Of Ph,Buffer Composition,And Ionic Strength. The 4-And 5-Pyrrolizinyl-2-Halopyridinium Iodides And The Corresponding Pyridones Were Evaluated Against P388 Lymphocytic Leukemia In Vivo. The Alpha-Fluoropyridinium Compounds Were Active But The Alpha-Chloro Compounds Were Not. This Activity Was Correlated With The Rates Of Hydrolysis Of The Alpha-Halopyridinium Compounds To The Active Pyridone. Compounds That Were Active In The P388 Screen Were Evaluated In L1210 Leukemia,M5076 Carcinoma,And Mx-1 Mammary Xenograft Assays In Mice.
DOI:10.1021/jm00168A021