CAS: 555-60-2; (3-Chlorophenyl)Carbonohydrazonoyl Dicyanide

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CAS号68657-31-8 alpha-(2-(2,2-d...

📜Alpha-(2-(2,2-Dicyanovinyl)-2-(3-Chlorophenyl)Hydrazono)Malononitrile置于三乙胺体系中,化学反应生成 羰基氰化氯苯腙
参考文献:Periselective Addition Of Mesoionic Compounds To Tetracyanoethylene. Preparation Of [(Dicyanovinyl)Hydrazono]Malononitriles
标题:Periselective Addition Of Mesoionic Compounds To Tetracyanoethylene. Preparation Of [(Dicyanovinyl)Hydrazono]Malononitriles
摘要:
DOI:10.1021/jo01328A013

专利信息

专利号:US-2025282825-A1
优先权日:2020-11-20
标 题 :Novel cyclic compounds, method for their preparation and the use of said cyclic compounds in cosmetic preparations
发明人：WIRTZ SEBASTIAN N; GROND STEPHANIE; SAUR JULIAN S; KRISMER BERNHARD; HEUER ANDREA; HUEPEDEN JENNIFER
权利人:UNIV EBERHARD KARLS TUEBINGEN
摘要:The present invention relates to novel cyclic compounds; a method for the solid phase synthesis of said novel cyclic compounds; novel thiazolidine and oxazolidine building blocks that can be directly incorporated into the solid phase synthesis of said novel cyclic compounds, and a novel method for the synthesis of said thiazolidine and oxazolidine building blocks; and cosmetic compositions containing said novel cyclic compounds.

专利号:US-9650621-B2
优先权日:2012-10-12
标 题:Proteolytic inactivation of select proteins in bacterial extracts for improved expression
发明人：THANOS CHRISTOPHER D; MURRAY CHRISTOPHER J; YANG JUNHAO; STEPHENSON HEATHER
权利人:SUTRO BIOPHARMA INC
摘要:The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1. The proteins can be modified in an exposed surface motif to incorporate OmpT1 cleavage sites. Also provided are nucleic acids encoding the modified proteins, bacterial cells that express the modified proteins, and cell free synthesis systems containing modified RF1. The disclosure further provides methods for reducing the deleterious activity of a modified protein in a cell free synthesis system by contacting the modified protein with OmpT1. Also provided are methods for reducing RF1 competition at an amber codon in the cell free synthesis system, and methods for expressing a protein in the cell free synthesis system. The modified proteins of the invention can be used to increase the yield of proteins having non-natural amino acids incorporated at an amber codon.

专利号:US-2022089690-A1
优先权日:2020-09-14
标 题 :Method for large scale production of antibodies using a cell-free protein synthesis system
发明人：YIN GANG
权利人:SUTRO BIOPHARMA INC
摘要:Described herein are methods for large scale production of antibodies using a cell-free protein synthesis system. The methods include expressing a heavy chain (HC) polypeptide of an antibody from a nucleic acid encoding the heavy chain in a cell-free bacterial extract in the presence of a light chain (LC) polypeptide, thereby producing the antibody. The methods are performed at a large scale that is suitable for commercial production of antibodies, for example in a reaction volume equal to or greater than about 10 liters, for example about 10 to about 25,000 liters. The methods result in increased yields per unit volume of properly folded and assembled antibodies as opposed to synthesizing the light chain in the same cell-free protein synthesis system as the heavy chain polypeptide.

专利号:US-2003124634-A1
优先权日:1996-04-30
标 题 :Novel proteins involved in the synthesis and assembly of O-antigen in pseudomonas aeruginosa
发明人：LAM JOSEPH S; BURROWS LORI L; CHARTER DEBORAH; KIEVIT TERESA DE
权利人:UNIV GUELPH
摘要:Novel nucleic acid molecules encoding proteins involved in the synthesis and assembly of O-antigen in P. aeruginosa ; and novel proteins encoded by the nucleic acid molecules are described. Methods are disclosed for detecting P.aeruginosa in a sample by determining the presence of the proteins or a nucleic acid molecule encoding the proteins in the sample.

专利号:US-2010113816-A1
优先权日:2006-12-29
标题:Method for prepartion of substituted adamantylarymagnesium halides
发明人：KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR
权利人:KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR
摘要:The present invention concerns fine organic synthesis, particularly the method for preparing of substituted adamantylarylmagnesium halides. n The known methods for preparing Grignard's reagent from substituted adamantylarylhalide give very low yeld of the desired product. Substituted adamantylarylhalides are active intermediates that by interacting with various electrophiles provide for a wide range of biologically active compounds. n The aim of current invention was to develop a method for preparing substituted adamantylarylmagnesium halides. The aim was attained adding lithium chloride in the Grignard's reagent synthesis by acting on is magnesium metal in dry tetrahydrofuran under argon by substituted adamantylarylhalide. n It was demonstrated that adding lithium chloride to adamantylarylhalide within a range from 1:1 to 1:2 provides for stable high yield of the desired end product.

专利号:US-11472777-B2
优先权日:2015-09-14
标题:Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction
发明人：SHOSHAN-BARMATZ VARDA; LEV GRUZMAN ARIE
权利人:NAT INST BIOTECHNOLOGY NEGEV LTD
摘要:Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's and Parkinson's diseases.