CAS: 548-54-9; Violacein

上下游产品

3-[5-(6-Benzyloxy-1,3A-Dihydrocyclohepta[b]Pyrrol-3-yl)-2-Oxo-1,2-Dihydropyrrol-3-Ylidene]-1,3-Dihydroindol-2-One 348128-39-2
(E)-3-(5-(5-(Benzyloxy)-1H-Indol-3-yl)-1-(4-Methoxybenzyl)-2-Oxo-1H-Pyrrol-3(2H)-Ylidene)Indolin-2-One 1429218-35-8
2-(5-Benzyloxy-1-Tert-Butoxycarbonyl-1H-Indol-3-yl)-5-Oxopyrrolidine-1-Carboxylic Acid Tert-Butyl Ester 348128-42-7
5-(5-(Benzyloxy)-1H-Indol-3-yl)-1-(4-Methoxybenzyl)-1H-Pyrrol-2-(5H)-One 1429218-34-7

📜5-苄氧基吲哚置于palladium On Activated Charcoal 盐酸,4-二甲氨基吡啶,1,4-环己二烯,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应 6.33H,反应生成 紫色杆菌素
参考文献:A Short Synthesis Of The Bacterial Pigments Violacein And Deoxyviolacein
标题:A Short Synthesis Of The Bacterial Pigments Violacein And Deoxyviolacein
摘要:描述了细菌色素脱氧紫色素 (1A) 和紫色素 (1B) 的简明合成,其中两个吲哚单元逐步连接到中心吡咯啉酮环.
DOI:10.1055/s-2001-12776

专利信息

专利号:US-4520103-A
优先权日:1982-10-27
标题:Microbial production of indigo
发明人：ENSLEY JR BURT D
权利人:AMGEN
摘要:Microbial synthesis of indigo dyestuff in indole-free media is disclosed. Indigo production is preferably accomplished by genetic transformation of selected host cells having the capacity to produce and accumulate indole (either as a result of endogenous genomic capacity or genetic transformation) to incorporate the capacity for synthesis of an aromatic dioxygenase enzyme. Growth of transformed cells under suitable conditions facilitates aromatic dioxygenase enzyme catalyzed oxidative transformation of cellular indole, with consequent formation of indigo from the oxidized reaction products. In a highly preferred embodiment, E. coli cells having endogenous indole production capacity are transformed with a DNA expression vector comprising the structural gene for naphthalene dioxygenase, resulting in the microbial synthesis of isolatable quantities of indigo.

专利号:US-2024425890-A1
优先权日:2022-02-11
标 题:Process for the synthesis of alpha-methylene-gamma-butyrolactone
发明人：TADEN ANDREAS; BECK HORST; MYRTOLLARI KAMELA; KOURIST ROBERT; NIGL ANDREA
权利人:HENKEL AG & CO KGAA
摘要:The present application provides a process for the preparation of α-methylene-γ-butyrolactone, said process comprising the steps of:a) acetylating the C1-hydroxyl group of isoprenol to yield isoprenyl acetate;b) forming 4-acetoxy-2-methylene-butan-1-ol from said isoprenyl acetate by whole cell biotransformation, said step comprising:i) contacting a cell (CB) with a culture medium containing said isoprenyl acetate or with a culture medium contiguous with an organic phase containing said isoprenyl acetate under conditions that enable the cell to form 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate; and,ii) optionally isolating the resultant 4-acetoxy-2-methylene-butan-1-ol, wherein said cell (CB) exhibits activity of at least one alkane monooxygenase enzyme which catalyzes the formation of 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate;c) oxidizing said 4-acetoxy-2-methylene-butan-1-ol to yield 4-acetoxy-2-methylene butyric acid; and,d) converting said 4-acetoxy-2-methylene butyric acid to α-methylene-γ-butyrolactone by hydroxylysis to γ-hydroxy-α-methylenebutyric acid and subsequent cyclization of said γ-hydroxy-α-methylenebutyric acid.

专利号:US-2015159180-A1
优先权日:2012-07-16
标题 :Process for production of crystalline xylitol using pichia caribbica and its application for quorum sensing inhibition
发明人：PRABHUNE ASMITA ASHUTOSH; LAXMAN KASTURI; MUKHERJI RUCHIRA ARUP
权利人:COUNCIL SCIENT IND RES
摘要:The inventors disclose a novel room temperature process for the synthesis of crystalline xylitol with high yield and purity from D-xylose using Pichia caribbica yeasts that acts as a quorum sensing antagonist that prevents bio film formation by gram-negative bacteria. Further a mild and safe procedure for xylitol extraction is disclosed.

专利号:US-2023399688-A1
优先权日:2015-08-20
标 题 :Compositions and multiplexed systems for coupled cell-free transcription-translation and protein synthesis and methods for using them
发明人：CULLER STEPHANIE; CHEN IHSIUNG BRANDON; PHARKYA PRITI; VAN DIEN STEVE; BARTON NELSON
权利人:GENOMATICA INC
摘要:In alternative embodiments, provided herein are transcription/translation (TX-TL) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the combinatorial biosynthesis of natural products (NPs), natural product analogs (NPAs) and secondary metabolites. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the rapid prototyping of complex biosynthetic pathways as a way to rapidly assess combinatorial and biosynthetic designs before moving to cellular hosts. In alternative embodiments, these exemplary TX-TL systems are multiplexed for high-throughput (HT) automation and for prototyping engineered platforms for the synthesis or modification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites analogs.

专利号:US-10988571-B2
优先权日:2018-07-27
标题 :Quorum sensing based polymer for stimulation of biofilms and related phenotypes, and synthesis process thereof
发明人：BISWA PRAMAL; RAJASHEKHAR BIJJA
权利人:FIB SOL LIFE TECH PRIVATE LIMITED
摘要:The invention relates to the synthesis and process thereof of a Quorum Sensing (QS) based polymer formed by the process of ring opening polymerization/ring opening copolymerization. The formed homopolymer or heteropolymer or copolymer displays increased half-life, bioactivity and biostability in stimulating the microbial quorum sensing in a predetermined microbial population.

专利号:SI-23510-A
优先权日:2010-10-22
标题 :An improved synthesis of a biosynthesis product with the targeted compilation of biosynthetic enzymes on the nucleotide sequence motif