CAS: 4825-86-9; ((R)-8-Hydroxy-3-Methyl-1-Oxoisochromane-7-Carbonyl)-L-Phenylalanine

上下游产品

°Chratoxin A 2'-Deoxyguanosine GLUTATHIONE(-)-3,4-dihydro-8-hydroxy-3-methyl-7-is°Coumarincarboxylic acid L-phenylalanine

📜赭曲霉毒素a置于葡萄糖,水体系中,化学反应 0.08H,以20%的收率获得产物赭曲霉素
参考文献:ochratoxin A Acts As A Photoactivatable Dna Cleaving Agent
标题:ochratoxin A Acts As A Photoactivatable Dna Cleaving Agent
摘要:赭曲霉毒素a通过光诱导产生dna断裂的能力被描述;在dna存在的情况下,光反应产生非氯化的衍生物赭曲霉毒素b,而在无氧条件下则反应生成氢醌衍生物.
DOI:10.1039/a708275D

专利信息

专利号:US-4346039-A
优先权日:1981-03-19
标 题 :Synthesis of ochratoxins
发明人：KRAUS GEORGE A
权利人:UNIV IOWA STATE RES FOUND INC
摘要:A simple, direct synthesis route is provided for Ochratoxin compounds, particularly Ochratoxin A, Ochratoxin B, and Ochratoxin C. The reaction involves treating the dimethyl ester of 2-hydroxy-4-methylbenzene-1,3-dioic acid with a deprotonating agent, followed by addition of acetaldehyde, to provide a precursor compound, which can conveniently be converted to Ochratoxins A, B or C. The synthesis route allows for the first time laboratory and industrial scale synthesis of ochratoxins A, B and C in large quantities and pure form making them available as toxins, for use as anti-toxin investigation works, and for biological activity investigations and residue studies.

专利号:US-7459443-B2
优先权日:1999-04-08
标 题 :Synthesis of biologically active compounds in cells
发明人：SERGEEV PAVEL
权利人:SERGEEV PAVEL
摘要:This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of determined sequence. The method is based on the hybridization of two or more oligomers bound with biologically inactive precursors of biologically active substances to specific RNA or DNA in vivo in the cells of living organisms. After hybridization of the oligomers to RNA or DNA the biologically inactive precursors bound to the 5′ and/or 3′ ends of the oligomers can interact with each other to make biologically active form of the substances. This changing of properties is due to chemical reactions which bind the biologically inactive precursors through a chemical bond into a biologically active form of the whole compound.

专利号:US-2022249576-A1
优先权日:2021-02-09
标 题:Method of disrupting mycotoxin synthesis using a composition comprising vibrio gazogenes
发明人：CHANDA ANINDYA
权利人:Mycologics LLC
摘要:A method of inhibiting mycotoxin synthesis in filamentous fungi comprises contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC. Additionally, infections caused by filamentous fungi can be inhibited by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942. Endosomal function in filamentous fungi can be disrupted by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942. Hyphal fusion formation can be restricted in filamentous fungi by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942.

专利号:BR-PI1102271-A2
优先权日:2011-05-26
标 题:Process for the total synthesis of enantiomerically pure ochratoxin alfa and its application in the synthesis of ochratoxin a

专利号:US-2005026143-A1
优先权日:1999-04-08
标 题:Synthesis of biologically active compounds in cells

专利号:WO-2007083345-A1
优先权日:2006-01-23
标 题:A competitive immunoassay for patulin detection
发明人：D AURIA SABATO; ROSSI MOSE; BAZZICALUPO PAOLO; DE CHAMPDORE MARCELLA
权利人:D AURIA SABATO; ROSSI MOSE; BAZZICALUPO PAOLO; DE CHAMPDORE MARCELLA
摘要:A method to detect the content of patulin in foods is based on the use of polyclonal antibodies produced against the mycotoxin patulin by means of two synthetic derivatives (4) and (5) of the molecule conjugated to bovine serum albumin as carrier protein. The invention comprises also the synthesis of said patulin derivatives and the preparation of affinity columns used to develop an immunofluorescence competitive assay for the detection of patulin. (Formula 5 and 4).