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专利信息
专利号:US-6417396-B1
优先权日:1997-09-24
标 题 :Quenching reagents for solution phase synthesis
发明人:NIKAM SHAM
权利人:WARNER LAMBERT CO
摘要:A method for enhancing the purity of a desired compound comprising:Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is capable of selective covalent reaction with unwanted byproducts, or excess reagents;Step (b) allowing the quenching agent to covalently react with unreacted starting materials and/or byproducts to afford a derivatized compound of the quenching agent: andStep (c) isolating the desired compound is described as well as novel quenching agents and methods for their use in the rapid purification of synthetic intermediates and products in synthesis, combinatorial chemistry, and automated organic synthesis.
专利号:US-6395930-B1
优先权日:1998-09-21
标题 :Quenching reagents for solution phase synthesis
发明人:NIKAM SHAM
权利人:WARNER LAMBERT CO
摘要:A method for enhancing the purity of a desired compound comprising:Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is capable of selective covalent reaction with unwanted byproducts, or excess reagents;Step (b) allowing the quenching agent to covalently react with unreacted starting materials and/or byproducts to afford a derivatized compound of the quenching agent: andStep (c) isolating the desired compound is described as well as novel quenching agents and methods for their use in the rapid purification of synthetic intermediates and products in synthesis, combinatorial chemistry, and automated organic synthesis.
专利号:JP-H06507378-A
优先权日:1990-11-21
标题:Synthesis of equimolar mixtures of oligomers, especially mixtures of oligopeptides
专利号:JP-3523252-B2
优先权日:1990-11-21
标题:Synthesis of equimolar multi-oligomer mixtures, especially oligopeptide mixtures