CAS: 3352-87-2; N,N-Diethyldodecanamide

相似化合物

1114-76-7 4088-41-9 2602-61-1

上下游产品

CAS号112-54-9 十二醛 | CAS号2523-98-0 N-dichlorophosp... | CAS号109-89-7 二乙胺 | CAS号112-16-3 十二酰氯 | CAS号143-07-7 月桂酸 | CAS号33641-61-1 N-diethylsulfin... | CAS号143593-91-3 N,N-diethyldode... | CAS号35902-57-9 N-Ethyl-1-dodec... | CAS号3007-31-6 双十二烷基胺 | CAS号112-53-8 月桂醇 | CAS号4271-27-6 N,N-diethyldode...

月桂酸置于氯化亚砜体系中,用 乙醚 作为反应溶剂,化学反应生成 N,N-二乙基十二酰胺
参考文献:Dodecanoic Acid Derivatives: Synthesis,Antimicrobial Evaluation And Development Of One-Target And Multi-Target Qsar Models
标题:Dodecanoic Acid Derivatives: Synthesis,Antimicrobial Evaluation And Development Of One-Target And Multi-Target Qsar Models
摘要:In This Study A Series Of Dodecanoic Acid Derivatives (1-30) Were Synthesized And Evaluated For In Vitro Antimicrobial Activity Against The Panel Of Gram Positive,Gram Negative Bacterial And Fungal Strains. 4-Nitro Phenyl Dodecanoate (4) And Quinolin-8-Yl Dodecanoate (5) Emerged As Most Effective Antibacterial Agents,And 1-(4-Benzylpiperazin-1-yl) Dodecan-1-One (15) Was Found To Be The Most Effective Antifungal Agent Amongst The Synthesized Dodecanoic Acid Derivatives. Quantitative Structure Activity Relationship (Qsar) Studies Performed By The Development Of One-Target And Multi-Target Models Indicated That Multi-Target Model Was Effective In Describing The Antimicrobial Activity Of Dodecanoic Acid Derivatives As Well Demonstrated The Importance Of Topological Parameter,Zero-Order Molecular Connectivity Index ((0)Chi).
DOI:10.1007/s00044-010-9383-5

专利信息

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.

专利号:US-5350681-A
优先权日:1986-08-18
标题 :Enzymatic membrane method for the synthesis and separation of peptides
发明人：IACOBUCCI GUILLERMO A; BROSE DANIEL J; RAY RODERICK J; VAN EIKEREN PAUL
权利人:COCA COLA CO
摘要:The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an N-terminal ammonium group or a protected amino acid having an alpha ammonium group in the presence of a condensation enzyme under conditions in which the carboxylate group and the ammonium group condense to form a protected, uncharged, peptide product. This peptide product is transported across a water-immiscible hydrophobic phase into an aqueous product phase and prevented from back diffusing across the water-immiscible hydrophobic phase. The peptide product can be converted, chemically or enzymatically, to a charged species that cannot back diffuse across the water-immiscible phase into the aqueous reaction phase. The water-immiscible hydrophobic phase is an ion rejection membrane separating the aqueous reaction phase from the product phase creating oil/water interfaces with each of the aqueous phases.

专利号:WO-2024083746-A1
优先权日:2022-10-17
标 题 :Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.

专利号:US-5002871-A
优先权日:1986-08-18
标 题:Enzymatic membrane method for the synthesis and separation of peptides
发明人：IACOBUCCI GUILLERMO A
权利人:COCA COLA CO
摘要:The present invention provides a membrane method for the enzymatic synthesis of peptides accomplished by shifting the chemical equilibrium that exists in a reaction mixture between charged or ionized reacting amino acids and uncharged or non-ionized peptide product in the presence of a proteolytic enzyme such as thermolysin. The equilibrium is shifted by diffusion of the unchanged peptide product across an ion-rejection membrane which removes the uncharged peptide from the reaction mixture and preferably the diffused uncharged peptide is quickly converted to a charged species that cannot back-diffuse into the reaction mixture so that the uncharged peptide is effectively 'pulled' across the membrane. An enzymatic conversion of the uncharged species utilizing an esterase having proteolytic activity such as aminoacylase I is disclosed. Copermeating reactants can be separated from the product mixture and returned to the reaction mixture. Also, the ion-rejection membrane can be utilized to resolve enantiomers of racemic carboxylic acids including D,L-amino acids.

专利号:US-5336601-A
优先权日:1986-08-18
标 题:Enzymatic membrane method for the snythesis and separation of peptides
发明人：IACOBUCCI GUILLERMO A
权利人:COCA COLA CO
摘要:The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an N-terminal ammonium group or a protected amino acid having an alpha ammonium group in the presence of a condensation enzyme under conditions in which the carboxylate group and the ammonium group condense to form a protected, uncharged, peptide product. This peptide product is transported across a water-immiscible hydrophobic phase into an aqueous product phase. This peptide product is removed from the aqueous product phase to prevent back diffusion across the water-immiscible hydrophobic phase. Reverse osmosis and other separation techniques may be utilized to remove the peptide product. The water-immiscible hydrophobic phase is an ion rejection membrane separating the aqueous reaction phase from the product phase creating oil/water interfaces with each of the aqueous phases.