CAS: 313348-27-5; 1-(6-Amino-9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-9H-Purin-2-yl)-N-Methyl-1H-Pyrazole-4-Carboxamide

上下游产品

瑞加德松杂质3 2-(4-Methoxycarbonylpyrazol-1-yl)Adenosine 1423073-21-5
1-(6-氨基-9-Beta-D-呋喃核糖基-9H-嘌呤-2-基)-1H-吡唑-4-羧酸乙酯 2-(4-Ethoxycarbonylpyrazol-1-yl)Adenosine 313348-16-2
2-氯腺嘌呤核苷 2-Chloroadenosine 146-77-0
2-碘腺苷 2-Iodoadenosine 35109-88-7
2-肼基腺苷 2-Hydrazinoadenosine 15763-11-8
2-氟腺苷 2-Fluoroadenosine 146-78-1
2-Chloro-2',3'-O-Isopropylideneadenosine 24639-06-3
1-(6-Amino-9H-Purin-2-yl)-N-Methyl-1H-Pyrazole-4-Carboxamide 1702334-23-3

2-氯腺嘌呤核苷置于高氯酸,Potassium Tert-Butylate体系中,用 乙醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成瑞加德松
参考文献: A Process For The Preparation Of Regadenoson[fr] Procédé De Préparation De Régadénoson
标题: A Process For The Preparation Of Regadenoson[fr] Procédé De Préparation De Régadénoson
摘要:本发明提供了制备具有化学式(I)的雷加诺生的新型工艺.在某些实施例中,还提供了合成雷加诺生的中间体.

专利信息

专利号:US-8859522-B2
优先权日:2011-04-27
标题:Processes for the preparation of regadenoson and a new crystalline form thereof
发明人：WOOLDRIDGE LUZVIMINDA T; MA CHUN; NADJI SOURENA
权利人:WOOLDRIDGE LUZVIMINDA T; MA CHUN; NADJI SOURENA; RELIABLE BIOPHARMACEUTICAL CORP
摘要:This disclosure relates to an improved process for the preparation of regadenoson, pharmaceutically acceptable salts thereof, and hydrates thereof, and for the preparation of intermediates useful in the synthesis of regadenoson. The disclosure also relates to a new crystalline form of regadenoson. Processes for the preparation of the crystalline form, compositions containing the crystalline form, and methods of use thereof are also described.

专利号:US-9771390-B2
优先权日:2013-12-10
标题:Process for the preparation of regadenoson
发明人：ZHANG XIAOHENG; MEI LIJUN
权利人:SCINOPHARM TAIWAN LTD
摘要:The present invention provides novel processes for the preparation of regadenoson having the formula (I). In some embodiments, the intermediates for the synthesis of regadenoson are also provided.

专利号:US-RE47301-E
优先权日:2006-02-03
标题 :Process for preparing an A2A-adenosine receptor agonist and its polymorphs
发明人：ZABLOCKI JEFF; ELZEIN ELFATIH; SEEMAYER ROBERT; LEMONS TRAVIS
权利人:GILEAD SCIENCES INC
摘要:Disclosed is a synthesis suitable for large scale manufacture of an A 2A -adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific polymorph.