CAS: 29943-42-8; Dihydro-2H-Pyran-4(3H)-One

相似化合物

2081-44-9 61128-73-2 119124-53-7

上下游产品

CAS号108-97-4 4H-吡喃-4-酮 | CAS号84302-42-1 2H-吡喃-4(3H)-酮 | CAS号2081-44-9 四氢吡喃-4-醇 | CAS号3592-25-4 1,5-二氯-3-戊酮 | CAS号57260-92-1 4-methylsulfiny... | CAS号64-17-5 乙醇 | CAS号2919-05-3 pent-4-en-2-yn-1-ol | CAS号67728-90-9 1,5-dimethoxype... | CAS号53005-18-8 1,5-Dimethoxy-3... | CAS号105772-13-2 3,6-二氢-2H-吡喃-4-甲腈 | CAS号104681-92-7 4,4-二甲氧基四氢-2H-吡喃-3-醇 | CAS号4295-99-2 4-氰基四氢吡喃 | CAS号4677-18-3 4-(2-羟乙基)四氢吡喃 | CAS号33024-60-1 4-氨基四氢吡喃盐酸盐 | CAS号40191-32-0 4-氢吡喃-4-甲酰氯 | CAS号398137-19-4 1-(四氢吡喃-4-基)哌嗪 | CAS号39124-20-4 4-氨基四氢吡喃-4-甲酸 | CAS号4677-20-7 4-溴乙基四氢吡喃 | CAS号50675-18-8 四氢吡喃-4-甲醛

4-醛基四氢吡喃置于co(Nmp)2,氧气,三乙胺体系中,用 异丙醇 用作溶剂,化学反应 12.0H,以99%的收率获得四氢吡喃酮
参考文献:烷基醛的钴催化需氧氧化裂解:酮,酯,酰胺和 α-酮酰胺的合成
标题:烷基醛的钴催化需氧氧化裂解:酮,酯,酰胺和 α-酮酰胺的合成
摘要:开发了一种广泛适用的方法,通过容易获得的烷基醛的氧化 C-C 键裂解来合成酮,酯,酰胺.绿色且丰富的分子氧(o 2)用作氧化剂,贱金属(钴和铜)用作催化剂.该策略可以扩展到由伯醇合成酮和由醛合成α-酮酰胺的一锅法.
Doi:10.1002/chem.202101035

专利信息

专利号:US-8703952-B2
优先权日:2008-12-12
标题:Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates
发明人：WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID
权利人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID; WISTA LAB LTD
摘要:The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.

专利号:US-4895996-A
优先权日:1988-10-17
标 题 :Synthesis of alkenes from enamines via hydroboration
发明人：GORALSKI CHRISTIAN T; SINGARAM BAKTHAN; BROWN HERBERT C
权利人:PURDUE RESEARCH FOUNDATION; DOW CHEMICAL CO
摘要:Alkenes are prepared by the hydroboration of enamines followed by an elimination reaction to form the alkene. This process has wide applicability and is useful for the stereospecific synthesis of [Z] isomers. It is preferred to use 9-borabicyclo[3.3.1 nonane as the hydroborating agent and to use methanol to catalyze the elimination reaction.

专利号:US-5461156-A
优先权日:1993-03-31
标 题 :Stereocontrolled synthesis of cis-bicyclic compounds
发明人：KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C; SULLIVAN KEVIN A
权利人:LILLY CO ELI
摘要:This invention provides a process for the stereocontrolled synthesis of cis-bicyclic compounds, including cis-hexahydro-6-isoquinolones, cis-dihydroisochromanones, cis-dihydrothiochromanones, and cisbicyclo[4.4.0]dec-3-ene-2-ones.

专利号:WO-9946267-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-6951878-B2
优先权日:1998-03-12
标 题:Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)
发明人：MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILLIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2007129554-A1
优先权日:2005-10-24
标题 :Alpha functionalization of cyclic, ketalized ketones and products therefrom
发明人：HARRINGTON PETER J; KHATRI HIRALAL N; KHATRI SUDHA
权利人:HARRINGTON PETER J; KHATRI HIRALAL N; KHATRI SUDHA
摘要:Methodologies for the alpha-monohalogenation of acid sensitive ketones, especially cyclic, acid-sensitive, ketalized ketones. As one approach, the ketone is reacted with a halogen donor compound, e.g., N-chlorosuccinimide, in anhydrous, highly polar organic reagents such as dimethylformamide (DMF). As another monohalogenation approach, it has been observed that organic salts generated from amines and carboxylic acids catalyze the monohalogenation of ketalized ketone in reagents comprising alcohol solvent (methanol, ethanol, isopropanol, etc.). The monohalogenation is fast even at −5° C. The salt can be rapidly formed in situ from ingredients including amines and/or carboxylic acids without undue degradation of the acid sensitive ketal. Aryl ketones are monooxygenated using iodosylbenzene. This methodology is applied to monohalogenation of an acid sensitive monoketal ketone. The ability to prepare monohalogenated, acid sensitive ketones facilitates syntheses using halogenated, acid sensitive ketones. As just one example, facile synthesis of halogenated, acid sensitive ketones provides a new approach to synthesize the S-ketal-acid S-MBA (S-methylbenzylamine) salt useful as an intermediate in the manufacture of a glucokinase activator. As an overview of this scheme, a monohalogenated, cyclic, ketalized ketone is prepared using monohalogenation methodologies of the present invention. The halogenated compound is then subjected to a Favorskii rearrangement under conditions to provide the racemic acid counterpart of the desired chiral salt. The desired chiral salt is readily recovered in enantiomerically pure form from the racemic mixture.