CAS: 25629-50-9; 3-(2-Chlorophenyl)-5-Methylisoxazole-4-Carbonyl Chloride

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2-Chloro-N-Hydroxybenzimidoyl Chloride置于氯化亚砜,三乙胺,Potassium Hydroxide体系中,用 乙醇,二氯甲烷,水 用作溶剂,化学反应生成3-(2-氯苯基)-5-甲基-4-异恶唑甲酰氯
参考文献:2-(5-甲基-3-芳基异恶唑-4-甲酰胺基)-4-烷基噻唑-5-羧酸乙酯的合成及生物活性
标题:2-(5-甲基-3-芳基异恶唑-4-甲酰胺基)-4-烷基噻唑-5-羧酸乙酯的合成及生物活性
摘要:图形摘要 摘要 合成了一系列新型 2-(5-甲基-3-芳基异恶唑-4-甲酰胺基)-4-烷基噻唑-5-羧酸乙酯 I-1-6.所有目标化合物的结构均通过1H NMR,13C NMR,Ir,Ms和元素分析表征.评价了它们的杀真菌和除草活性.初步生物测定结果表明,标题化合物 I-4置于150 G Ai/ha 的剂量下对大多数受试植物具有 20-50% 的抑制作用,而标题化合物 I-1-5 具有 32-58% 的抑制作用以 100 Mg/l 的浓度在体外对 Fusahum Graminearum,Thanatephorus Cucumeris,Botrytis Cinereapers 和 Fusarium Oxysporum 有抑制作用.
Doi:10.1080/10426507.2017.1393423

专利信息

专利号:WO-2014072843-A1
优先权日:2012-11-07
标题 :Process for preparing isoxazolyl penicillins
发明人：GUJRAL RAJINDER SINGH
权利人:VARDHMAN CHEMTECH LTD; GUJRAL RAJINDER SINGH
摘要:The present invention relates to a process for the preparation of isoxazolyl penicillins from sugarcane juice. The invention focuses on in-situ synthesis of isoxazolyl penicillins without isolation of the intermediates like Penicillin G and 6-APA from the reaction sequence.

专利号:US-4172199-A
优先权日:1975-01-02
标题 :O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：BELLEAU BERNARD R; CONWAY TERRY T; DOYLE TERRENCE W; LUH BING-YU
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula wherein Z is hydrogen or the residue of an ester group and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-4113946-A
优先权日:1975-01-02
标题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：BELLEAU BERNARD R; DOYLE TERRENCE W; LUH BING YU; CONWAY TERRY T
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted Δ 2 ,3 -1,4-morpholine-2-carboxylic acids possessing a fused β-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Q is hydrogen, alkyl, aralkyl or --CH 2 COOZ where Z is hydrogen or the residue of an ester group and X is amino, azido or acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. Those compounds in which X is acylamino and their physiologically hydrolyzed esters and pharmaceutically acceptable salts are potent antibacterial agents.

专利号:CN-1228332-C
优先权日:2003-04-03
标 题:Chemical synthesis method of 3-(2-chlorophenyl)-5-methyl-4-isoxazolecarbonyl chloride

专利号:CN-1535960-A
优先权日:2003-04-03
标题:Chemical synthesis method of 3-2-chlorophenyl)-5-methyl-4-isoxazolecarbonyl chloride