专利号:US-11168050-B2 优先权日:2014-03-27 标 题 :Efficient synthesis of amines and amides from alcohols and aldehydes by using cascade catalysis 发明人:CÓRDOVA ARMANDO; BERGLUND PER; ANDERSON MATTIAS; AFEWERKI SAMSON 权利人:XP CHEMISTRIES AB 摘要:The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal- and organocatalysis. More specifically, the present invention relates to synthesis of capsaicinoids starting from vanillin alcohol and using a combination of an enzyme cascade system and catalysts. Furthermore, the method also relates to synthesis of capsaicinoids derivatives starting from vanillin alcohol derivatives and using a combination of an enzyme cascade system and catalysts.
专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:US-2007225490-A1 优先权日:2003-12-15 标 题:Cationic Oligomer of a Saccharide for Resolving Enantiomers and Asymmetric Synthesis 发明人:CHING CHI B; YOUNG DAVID J; MUDERAWAN I WAYAN; ONG TENG T; NG SIU C 权利人:SELEX SENSORS & AIRBORNE SYS 摘要:A cationic oligomer of a saccharide, wherein the saccharide is functionalized by a cationic group, for example an ammonium, phosphonium, imidazolium, or pyridinium group. In a preferred embodiment, the cationic oligomer of a saccharide is a cationic cyclodextrin. There is also provided a use of the cationic oligomer of a saccharide as a chiral agent for resolving enantiomers by a chromatographic method or an asymmetric synthesis.
专利号:US-10618030-B2 优先权日:2016-06-30 标 题:Metal oxide-based biocompatible hybrid sorbent for the extraction and enrichment of catecholamine neurotransmitters and related compounds, and method of synthesis 发明人:MALIK ABDUL; ALHENDAL ABDULLAH AWADH 权利人:UNIV SOUTH FLORIDA 摘要:The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO 2 polypropylene oxide based sol-gel. The subject invention also concerns a hollow tube or capillary internally coated with a sorbent of the invention. Sorbent coated tubes and capillaries of the invention can be used in extraction and/or enrichment of samples to be analyzed for catecholamines and related compounds.
专利号:EP-3122715-B1 优先权日:2014-03-27 标 题:Efficient synthesis of amines and amides from alcohols and aldehydes by using cascade catalysis
专利号:ES-2738902-T3 优先权日:2014-03-27 标题:Efficient synthesis of amines and amides from alcohols and aldehydes using cascade catalysis
参考文献:10.1007/s00405-004-0885-y 摘要:Işık ACÜ, Erem C, İmamoğlu M, Çinel A, Sarı A, Maral G. Familial paraganglioma. European Archives of Oto-Rhino-Laryngology. 2005 Nov 30;263(1):23–31. doi: 10.1007/s00405-004-0885-y. 参考文献:10.1186/1752-1947-5-310 摘要:Hou R, Leathersich AM, Ruud BT. Pheochromocytoma presenting with arterial and intracardiac thrombus in a 47-year-old woman: a case report. Journal of Medical Case Reports. 2011 Jul 13;5(1):310. doi: 10.1186/1752-1947-5-310.