CAS: 23668-11-3; Benzoic Acid,2-Hydroxy-6-Methyl-,[(1S,2R,3R,4S,5S)-5-[(3-Acetylphenyl)Amino]-4-Amino-3-[[(Dimethylamino)Carbonyl]Amino]-1,2-Dihydroxy-3-[(1S)-1-Hydroxyethyl]-2-Methylcyclopentyl]Methylester

上下游产品

Pactamycate 23754-55-4
[(1'S,2'R,4R,4'R,5S,5'S)-4'-Azido-1'-[[tert-Butyl(Diphenyl)Silyl]Oxymethyl]-2-(4-Methoxyphenyl)-5-Methylspiro[5H-1,3-Oxazole-4,3'-6-Oxabicyclo[3.1.0]Hexane]-2'-Yl]Oxy-Triethylsilane 1295471-16-7
(1'S,4R,4'R,5S,5'S)-4'-Azido-1'-[[tert-Butyl(Diphenyl)Silyl]Oxymethyl]-2-(4-Methoxyphenyl)-5-Methylspiro[5H-1,3-Oxazole-4,3'-6-Oxabicyclo[3.1.0]Hexane]-2'-One 1295471-17-8
(1'R,4R,4'R,5S,5'S)-5'-[[tert-Butyl(Diphenyl)Silyl]Oxymethyl]-2-(4-Methoxyphenyl)-5-Methyl-4'-Triethylsilyloxyspiro[5H-1,3-Oxazole-4,3'-6-Oxabicyclo[3.1.0]Hexane]-2'-One 1295471-10-1
(4S,5R,6S)-7-[[tert-Butyl(Diphenyl)Silyl]Oxymethyl]-2-(4-Methoxyphenyl)-4-Methyl-6-Triethylsilyloxy-3-Oxa-1-Azaspiro[4.4]Nona-1,7-Dien-9-One 1295471-06-5
Benzyl (4R,5S)-4-[(1S)-2-[[tert-Butyl(Diphenyl)Silyl]Oxymethyl]-1-Triethylsilyloxyprop-2-Enyl]-2-(4-Methoxyphenyl)-5-Methyl-5H-1,3-Oxazole-4-Carboxylate 1295471-02-1
1-[(4R,5S)-4-[(1S)-2-[[tert-Butyl(Diphenyl)Silyl]Oxymethyl]-1-Triethylsilyloxyprop-2-Enyl]-2-(4-Methoxyphenyl)-5-Methyl-5H-1,3-Oxazol-4-Yl]Ethanone 1295471-03-2

📜(2Z)-3-偶氮基-4-氧代-2-戊烯-2-醇置于2,6-二甲基吡啶,甲醇,4-二甲氨基吡啶,正丁基锂,Rh2(oct)4,20% Palladium Hydroxide-Activated Charcoal,四丁基氟化铵,氢气,双氧水,Sodium Methylate,Potassium Carbonate,辛可尼丁,臭氧,Lithium Tri-(Tert-Butoxy)Aluminum Hydride,三乙胺,二异丙胺,Sodium Hydroxide,Scandium Tris(Trifluoromethanesulfonate)体系中,用 四氢呋喃,甲醇,正己烷,二氯甲烷,N,N-二甲基乙酰胺,1,2-二氯乙烷,甲苯 用作溶剂,化学反应 59.58H,反应生成密旋霉素
参考文献: Synthetic Route To Pactamycin And Pactamycin Analogs[fr] Voie De Synthèse D'Analogues De La Pactamycine Et De La Pactamycine
标题: Synthetic Route To Pactamycin And Pactamycin Analogs[fr] Voie De Synthèse D'Analogues De La Pactamycine Et De La Pactamycine
摘要:描述了用于制备化合物(i)的方法和中间体,包括通过将亚胺与2-氨基取代的1,3-二羰基在mannich加成反应中反应以产生所述α,β-二氨基酮的一般方法.

专利信息

专利号:US-6200808-B1
优先权日:1995-03-29
标 题 :Induction of embryogenesis from plant microspores
发明人：SIMMONDS DAINA H; NEWCOMB WILLIAM; ZHAO JIPING; GERVAIS CARMEN
权利人:UNITED KINGDOM GOVERNMENT
摘要:Embryogenesis from plant microspores is routinely induced with a 16-24 h temperature treatment of 32.5° C. Continuous culture at 25° C. results in pollen development. However, microspore treatment with anti-cytoskeletal agents, or protein synthesis inhibitors, at the non-inductive temperature of 25° C., can induce embryogenesis, thus demonstrating that heat shock is not required for embryogenic induction. Furthermore, when anti-microtubule agents (e.g. colchicine) are used, embryo induction and chromosome doubling occur simultaneously, thus generating doubled haploids, whereas heat induction generates haploids. Thus, the use of microtubule inhibitors will provide a simple one-step process to simultaneously induce embryogenesis and chromosome doubling for the production of fertile plants, thus providing minimal manipulation which will be very advantageous for genetic studies and plant breeding programs. As noted, heat shock induces haploids. A low level of chromosome doubling can be obtained by adding colchicine to microspore cultures during the heat treatment. However, the use of trifluralin with the heat treatment, to generate doubled haploid plants results in an improved recovery of fertile doubled haploid plants than previously shown in the prior art.

专利号:WO-2008148054-A1
优先权日:2007-05-24
标题:Structures of aminoglycoside antibiotics bound to both subunits of the bacterial ribosome
发明人：ZHANG WEN; BOROVINSKAYA MARIA A; PAI RAJ D; CATE JAMIE H DOUDNA; HOLTON JAMES M
权利人:UNIV CALIFORNIA; ZHANG WEN; BOROVINSKAYA MARIA A; PAI RAJ D; CATE JAMIE H DOUDNA; HOLTON JAMES M
摘要:Antibiotics target many steps of bacterial protein synthesis, including mRNA and tRNA translocation on the ribosome and ribosome recycling. High resolution structures of the intact bacterial ribosome complexed with aminoglycoside antibiotics neomycin, gentamicin and kanamycin are described. The drugs have two primary binding sites on the ribosome, one in the helix 44 of the small ribosomal subunit, and one in the helix 69 (H69) of the large ribosomal subunit. Also provided are high resolution structures of the intact bacterial ribosome in complexes with ribosome recycling factor (RRF), and with RRF plus aminoglycosides gentamicin or paromomycin. Also provided the mechanism for how aminoglycoside binding in H69 affects ribosomal recycling and translocation. The data may be used for the structure-based modifications of clinically used aminoglycosides to ensure higher antibiotic potency of the drugs, as well as for the rational design and modeling of the new inhibitors for the ribosome, which can be used as antibiotics, based on the structural data on the new aminoglycoside binding site.

专利号:US-2010204310-A1
优先权日:2008-09-12
标题:New modalities for treatment of drug-resistant tuberculosis and other diseases
发明人：ZAMECNIK PAUL C; PIERSON KAREN; TABATADZE DAVID
权利人:ZATA PHARMACEUTICALS INC
摘要:The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of Mycobacterum tuberculosis selected from protein 30, 32A and 32B, and further having 5′ and 3′ palindromic hairpin-forming sequences, said compound being covalently linked to a protein synthesis inhibiting antibiotic via a linker. The invention further provides pharmaceutical formulations of such compounds and methods of use thereof for treating tuberculosis. Other diseases may similarly be treated by tethering and antibiotic which targets a ribosomal protein to an antisense oligonucleotide complementary to an mRNA involved in the disease.

专利号:CN-115896134-A
优先权日:2022-09-29
标题:An engineering strain of Bacillus brevis that improves the synthesis of idamectin and its construction method and application

专利号:US-4675295-A
优先权日:1981-10-28
标题:Process for producing subculturable lymphokine-producing human T cell hybridomas
发明人：OSAWA TOSHIAKI; KOBAYASHI YOSHIRO; ASADA MAKOTO; HIGUCHI MASAHIRO
权利人:DENKI KAGAKU KOGYO KK
摘要:A process for preparing human T cell hybridomas which are subculturable and produce lymphokines comprising the steps of: (1) treating a human acute leukemia cell with a protein and/or RNA synthesis inhibitor; (2) independently activating a human T cell with a mitogen or antigen; (3) fusing the thus-treated human acute leukemia cell with the thus-activated human T cell in the presence of a fusion accelerator; and (4) isolating the thus-formed hybridoma. An in vivo process for producing lymphokines using the hybridomas is also described.

专利号:US-11879138-B2
优先权日:2020-05-25
标 题:Method for preparing mesenchymal stem cell-derived exosomes and culture solution produced from the same
发明人：KIM JAE YOUNG; CHWAE YONG JOON
权利人:CK EXOGENE CO LTD
摘要:The present application provides a method for preparing mesenchymal stem cell-derived exosomes, the method including: obtaining a cell sample from mesenchymal stem cells and sub-culturing the cell sample, culturing the sub-cultured cells in a substrate medium containing a protein synthesis inhibitory enzyme, and then obtaining a cell culture solution, and isolating exosomes from the cell culture solution, and a cell culture solution produced therefrom. The method for preparing exosomes of the present application has an advantage in that high purity and high concentration exosomes can be isolated.