CAS: 2343-89-7; Methyl 2-Fluoroacrylate

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430-99-9 760-80-5 392-41-6

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CAS号55900-27-1 2-氟-3-氯丙酸甲酯 | CAS号50-00-0 甲醛 | CAS号453-18-9 氟乙酸甲酯 | CAS号2365-93-7 methyl 3-bromo-... | CAS号380-26-7 methyl α,β-dibr... | CAS号85345-88-6 Methyl 2-Fluoro... | CAS号67832-56-8 methyl 2R,3S-2,... | CAS号76548-29-3 methyl (2R,3R)-... | CAS号53510-07-9 2,3-Dichlor-2-f... | CAS号399-86-0 methyl 3-bromo-...

2,3-Dichlor-2-Fluor-Propansaeuremethylester置于硫酸,水,锌体系中,用52%的收率获得2-氟丙烯酸甲酯
参考文献:合成vonα-Fluoracrylsäure和derivaten
标题:合成vonα-Fluoracrylsäure和derivaten
摘要:Three New Routes To Derivatives Of Alpha-Fluoracrylic Acid,Including A Laboratory Synthesis And A Large-Scale Method,Are Reported. The Processes Are (I) Addition Of Elementary Fluorine To Acrylic Esters And Subsequent Elimination Of Hf; (II) Addition Of Difluorocarbene To Isopropenyl Methyl Ether,Oxidation Via Ring Opening And Dehalogenation; And (III) 'Nitrofluorination' Of 2,3-Dichloropropene,Hydrolysis And Dechlorination.
Doi:10.1016/s0022-1139(00)80116-5

专利信息

专利号:WO-2017109658-A1
优先权日:2015-12-23
标 题:Process for the synthesis of patiromer
发明人：GABOARDI MAURO; PRENDIN RICCARDO; CASTALDI MARTA; CASTALDI GRAZIANO
权利人:RJW PHARMA LLC
摘要:The present invention relates to a process for the synthesis of Patiromer, an active ingredient used in the treatment of hyperkalemia in adults.

专利号:WO-2025132814-A1
优先权日:2023-12-21
标 题:Novel synthesis of methyl-2-fluoroacrylate
发明人：BRUNKE JESSICA; FISCHER MICHAEL; WÖSSNER JAN STEPHAN
权利人:VIFOR INT AG
摘要:The present invention relates to novel synthesis methods of methyl 2-fluoroacrylate (MFA) which is a key precursor for the production of Veltassa® (Patiromer). The methods according to the invention are conducted by reacting an α-substituted β-hydroxy propionic acid derivative (I) via one or more intermediate steps involving one or more α-, β-substituted propionic acid derivatives (II) to obtain MFA (III).

专利号:CA-2952530-A1
优先权日:2014-06-18
标题:Synthesis of halogenated malonic acid diesters and use thereof in the synthesis of 2-halogen-acrylic acid esters

专利号:US-12441677-B2
优先权日:2019-11-14
标 题 :One step synthesis for alkyl 2-fluoroacrylates
发明人：JIN QINGWU; WHITACRE MICHAEL
权利人:VIFOR INT LTD
摘要:A process is provided that results in an alkyl haloacrylate that is produced by reaction of a dialkyl or diaryl halomalonate with an aldehyde, preferably formalin or paraformaldehyde, and a base catalyst to produce an intermediate that is not isolated and is heated to produce the alkyl haloacrylate. This synthesis can be one pot, meaning it reacts in the same vessel and/or reaction mixture and does not require isolation of the intermediate, and provides an improved yield. In particular, a process is provided that results in an alkyl 2-fluoroacrylate.

专利号:US-2023126376-A1
优先权日:2020-03-27
标 题 :Synthesis of methyl 2-fluoroacrylate

专利号:CA-3118086-A1
优先权日:2018-11-02
标题 :Synthesis of re-pulpable temporary wet strength polymer for tissue application