CAS: 2279-15-4; Z-D-Trp-Oh

上下游产品

CAS号501-53-1 氯甲酸苄酯 | CAS号153-94-6 D-色氨酸 | CAS号64-17-5 乙醇 | CAS号13058-16-7 苯甲氧羰基-DL-色氨酸 | CAS号56452-52-9 α-甲基-D-色氨酸 | CAS号153-94-6 D-色氨酸

(4-Nitrophenyl) (2R)-3-(1H-Indol-3-yl)-2-(Phenylmethoxycarbonylamino)Propanoate置于γ-环糊精体系中,用 乙腈 用作溶剂,化学反应生成N-苄氧羰基-D-色氨酸
参考文献:具有明显立体选择性的环糊精介导的氨基酸酯的脱酰作用.
标题:具有明显立体选择性的环糊精介导的氨基酸酯的脱酰作用.
摘要:关于由α-,β-和γ-环糊精(cyds)介导的zd(l)-氨基酸酯(n-(苄氧基羰基)-D(l)-氨基酸对硝基苯酯)的水解(脱酰)作用,观测到ala底物与γ-Cyd脱酰基的对映选择性非常高(l / D = 9.0).基于michaelis-Menten原理的动力学结果表明,对映选择性应主要源自γ-Cyd-底物(1:1)复合物形成后底物的脱酰基过程.还介绍了对包合物的计算机建模(分子力学)研究.
Doi:10.1248/cpb.50.1283

专利信息

专利号:WO-9209620-A1
优先权日:1990-11-30
标题 :Solution phase process for synthesis of peptide
发明人：STEVENSON DAVID
权利人:SMITHKLINE BEECHAM CORP
摘要:A solution phase process for preparing L-His-D-Trp-L-Ala-L-Trp-D-Phe-L-Lys-NH2, a peptide which has pituitary growth hormone releasing activity, is described.

专利号:EP-0564587-A4
优先权日:1990-11-30
标 题:Solution phase process for synthesis of peptide

专利号:EP-0564587-A1
优先权日:1990-11-30
标题 :Solution phase process for synthesis of peptide

专利号:IE-914157-A1
优先权日:1990-11-30
标 题:Solution phase process for synthesis of peptide

专利号:CN-106188231-B
优先权日:2015-05-25
标题 :Synthesis and application of pasireotide pentapeptide intermediate

专利号:CN-106188231-A
优先权日:2015-05-25
标题:Synthesis and Application of Pasiiretide Pentapeptide Intermediate