CAS: 20853-58-1; (4As,6As,6Br,8Ar,9R,10S,12Ar,12Br,14Bs)-10-(((2S,3R,4S,5S)-4,5-Dihydroxy-3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-9-(Hydroxymethyl)-2,2,6A,6B,9,12A-Hexamethyl-1,3,4,5,6,6A,6B,7,8,8A,
该化合物是主要与原生细胞细胞素植物分离的三叶杆状沙邦素化合物,它显示出显著的生物活动,包括抗炎,细胞毒性和免疫细胞性能,使它成为药理学研究的一个主题.Cauluside C的结构特征是,它附于一种三叶杆腺素的糖糖块,它显示了它作为药物开发的铅化合物的潜力,特别是在针对癌症和免疫相关途径方面.它的行动机制包括移动细胞信号路径,如NF-B和MAPK.该化合物还因其稳定性和生物利用率进行了研究,这对于治疗应用至关重要. Cauluside C通常作为高纯度的研究参考标准提供.
- 英文名称(4As,6As,6Br,8Ar,9R,10S,12Ar,12Br,14Bs)-10-(((2S,3R,4S,5S)-4,5-Dihydroxy-3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-9-(Hydroxymethyl)-2,2,6A,6B,9,12A-Hexamethyl-1,3,4,5,6,6A,6B,7,8,8A,
- 中文名称葳岩仙皂苷 C
- IUPAC名称(4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-10-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
- 其它别名Hederagenin 3-O-.Beta.-D-Glucopyranosyl(1->2)-O-.Alpha.-L-Arabinopyranosid; Alpha-Fatsin; Hederagenin 3-O-Beta-D-Glucopyranosyl(1->2)-O-Alpha-L-Arabinopyranosid; (4As,6Ar,6As,6Br,8Ar,9R,10S,12Ar,14Bs)-10-[(2S,3R,4S,5S)-4,5-Dihydroxy-3-[(2S,
- CAS编号20853-58-1
- MFCD编号:MFCD32182528
- FDA UNII编号:909OGZ2782
- 分子式:C41H66O13分子量:766.97
- 产品CID: 1060866
- 产品分类生物化工 → 提取物 → 植物提取物
物理性质
MSDS等安全信息
上下游产品
53H86O23C53H86O23 2)-α-L-arabinopyranoside> 28-O- 4)-O-β-D-glucopyranosyl-(1-> 6)-β-D-glucopyranoside>hederagenin 3-O- 2)-α-L-arabinopyranoside 28-O- 4)-O-β-D-glucopyranosyl-(1- 6)-β-D-glucopyranoside Medicoside C 2)-3,4-di-O-benzoyl-β-L-arabinopyranosyl]-23-O-benzoylhederagenateallyl 3-O-[2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-glucopyranosyl-(1-2)-3,4-di-O-benzoyl-β-L-arabinopyranosyl]-23-O-benzoylhederagenateD-Glucose L-(+)-arabinose hedaragenin prosapogenin合成工艺路线路线简述
📜在 Sodium Hydroxide体系中,用 1,4-二氧六环 用作溶剂,化学反应 3.0H,反应生成葳岩仙皂苷 C
参考文献:八角3,28-O-双糖苷三萜皂苷的结构
标题:八角3,28-O-双糖苷三萜皂苷的结构
摘要:摘要 从粳稻成熟果实中分离得到4种新型3,28-O-双糖苷三萜皂苷.它们被表征为 28-O-α-L-Rhamnopyranosyl-(1-> 4)-β-D-Glupyranosyl-(1-> 4)-β-D-吡喃葡萄糖苷 3-O-α-L-Arabinopyranosyl Echinocystic Acid,3-O-α-L-阿拉伯吡喃常春藤苷配基,3-O-β-D-吡喃葡萄糖基-(1->2)-α-L-阿拉伯吡喃齐墩果酸和3-O-β-D-吡喃葡萄糖基-(1->2) )-α-L-阿拉伯吡喃常春藤苷配基.
Doi:10.1016/s0031-9422(00)98554-6
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Likhatskaya GN, Aminin DL, Agafonova IG, Gnedoi SN, Shentsova EB, Strigina LI, Anisimov MM. The pH-dependent channels formed by cauloside C. Adv Exp Med Biol. 1996;404:239-49. doi: 10.1007/978-1-4899-1367-8_22. 122(1):45-51. doi: 10.1016/s1095-6433(98)10138-1. 22(11):1826. doi: 10.3390/molecules22111826.
4: Avula B, Wang YH, Rumalla CS, Ali Z, Smillie TJ, Khan IA. Analytical methods for determination of magnoflorine and saponins from roots of Caulophyllum thalictroides (L.) Michx. using UPLC, HPLC and HPTLC. J Pharm Biomed Anal. 2011 Dec 15;56(5):895-903. doi: 10.1016/j.jpba.2011.07.028. Epub 2011 Jul 29. 77(1):111-7. doi: 10.1021/np400758t. Epub 2013 Dec 11.
6: Prokof'eva NG, Likhatskaia GN, Aminin DL, Gafurov IuM, Sasunkevich VA, Strigina LI, Anisimov MM. Mekhanizm vzaimodeĭstviia pH-zavisimogo tsitostatika kaulozida C s memranami opukholevykh kletok i liposom [The mechanism of the interaction of the pH-dependent cytostatic cauloside C with the membranes of tumor cells and liposomes]. Izv Akad Nauk SSSR Biol. 1990 May-Jun;(3):338-42. Russian. 26(5):387-91. Russian. 101(4-5):226-31. doi: 10.1016/j.jsbmb.2006.06.022. Epub 2006 Sep 12.
合成参考文献
参考文献:10.1016/0031-9422(75)85355-6
摘要:Strigina LI, Chetyrina NS, Isakov VV, Elkin YN, Dzizenko AK, Elyakov GB. Cauloside D a new triterpenoid glycoside from Caulophyllum robustum maxim: Identification of cauloside A. Phytochemistry. 1975 Jul;14(7):1583–6. doi: 10.1016/0031-9422(75)85355-6.
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