CAS: 1978-38-7; N-Methyl-2-Fluoroaniline

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CAS号824-48-6 N-(2-fluorophen... | CAS号64-18-6 甲酸 | CAS号348-54-9 邻氟苯胺 | CAS号74-88-4 碘甲烷 | CAS号900537-29-3 Benzenesulfonam... | CAS号68-11-1 硫代乙醇酸(TGA) | CAS号1766-57-0 N-nosyl-o-fluor... | CAS号61-50-7 N,N-二甲基色胺 | CAS号475039-81-7 4-溴3-甲基吲哚 | CAS号875-30-9 1,3-二甲基-1H-吲哚 | CAS号1484-12-4 N-甲基咔唑 | CAS号27799-79-7 5,6-dihydrophen... | CAS号826-72-2 1-甲基-3,4-二氢-1H-... | CAS号40141-98-8 5-methyl-[1,3]d...

N-(2-Fluorophenyl)Methanimine置于氢气体系中,120.0 °C,1.0 Mpa 条件下,反应 3.0H,以96.6%的收率获得n-甲基-2-氟苯胺
参考文献:一种n-甲基邻氟苯胺的合成方法
标题:一种n-甲基邻氟苯胺的合成方法
摘要:本发明公开了一种n‑甲基邻氟苯胺的合成方法,包括如下步骤:包括如下步骤:(1)以邻氟苯胺为原料,加入甲苯,多聚甲醛和催化剂a,保温反应后脱水,经后处理得n‑亚甲基邻氟苯胺;(2)将n‑亚甲基邻氟苯胺,催化剂b装入高压釜,氮气置换后,通入氢气并保持一定压力,升温进行加氢反应,经后处理得n‑甲基邻氟苯胺.该方法能具有原料易得,反应条件温和,原料成本较低,避免二甲基化杂质等巨大优势,具有较大的工业化应用前景.

专利信息

专利号:US-2022315528-A1
优先权日:2019-08-21
标题:Inhibitors of phospholipid synthesis and methods of use
发明人：GOUW ARVIN; SCHOW STEVEN R; GREENHOUSE ROBERT J; KLINE TONI; FELSHER DEAN W
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation.

专利号:WO-2021016413-A1
优先权日:2019-07-23
标 题 :Synthesis of bicyclic inhibitors of histone deacetylase

专利号:CN-110863020-A
优先权日:2019-12-19
标 题:A kind of method for enzymatic synthesis of oxazolam

专利号:KR-20220169970-A
优先权日:2021-06-21
标题 :Method for synthesis of aminobenzyne and multisubstituted organic nitrogen compounds using aza-brook rearrangement and multisubstituted organic nitrogen compounds prepared using the same

专利号:WO-0050406-A1
优先权日:1999-02-22
标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAEL
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.

专利号:US-7176312-B2
优先权日:2001-10-12
标 题:Kinase inhibitor scaffolds and methods for their preparation
发明人：DING SHENG; DING QIANG; GRAY NATHANAEL S
权利人:IRM LLC
摘要:General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines at elevated temperature or by anilines, boronic acids and phenols via palladium catalyzed cross-coupling reactions.