CAS: 148516-15-8; (S,E)-6-(2-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)Vinyl)-5,6-Dihydro-2H-Pyran-2-One

英文名称(S,E)-6-(2-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)Vinyl)-5,6-Dihydro-2H-Pyran-2-One
中文名称匹伐他汀杂质34
IUPAC名称(S,E)-6-(2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-5,6-dihydro-2H-pyran-2-one
其它别名(S,E)-6-(2-(2-Cyclopropyl-4-; 2H-Pyran-2-One, 6-[(1E)-2-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]Ethenyl]-5,6-Dihydro-, (6S)-; (6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]Ethenyl]-5,6-Dihydro-2H-Pyran-2-One; (S,E)-6-(2-(-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)Vinyl)-5,6-Dihydro-2H-Pyran-2-One; (S,E)-6-(2-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)Vinyl)-5,6- Dihydro-2H-Pyran-2-One; (S,E)-6-(2-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)Vinyl)-5,6-Dihydro-2H-Pyran-2-One? (Pitavastatin Impurity）
CAS编号148516-15-8
FDA UNII编号:PUS9XN5NPL
分子式:C25H20FNO2分子量:385.44
产品CID: 712832
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: MFFUQPAEKQJJQL-IQGVVSCOSA-N
InChI=1S/C25H20FNO2/c26-18-12-10-16(11-13-18)24-20-5-1-2-6-22(20)27-25(17-8-9-17)21(24)15-14-19-4-3-7-23(28)29-19/h1-3,5-7,10-15,17,19H,4,8-9H2/b15-14+/t19-/m0/s1
计算化学: 氢键受体数4.0氢键供体数*可旋转键数4.0

MSDS等安全信息

上下游产品

(S)-1-chloro-2-hydroxy-5-trimethylsilyl-4-pentyne (S)-2-(3-trimethylsilyl-2-propynyl)oxirane 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 2-cyclopropyl-4-(4-fluoro-phenyl)-3-quinoline carboxylic acid ethyl ester (1R,4S,6R)-4-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-3,7-dioxa-bicyclo[4.1.0]heptan-2-one

合成工艺路线路线简述

合成目标产物 Pitavastatin Impurity 29 主要起始原料 2-Cyclopropyl-4-(4-Fluorophenyl)-Quinolyl-3-Methanol
(文献来源)合成步骤主要原料 2-Cyclopropyl-4-(4-Fluorophenyl)-Quinolyl-3-Methanol

📜(S)-1-Chloro-2-Hydroxy-5-Trimethylsilyl-4-Pentyne置于lindlar Catalyst 氢氧化钾,正丁基锂,氢气,Sodium Acetate,4-甲基苯磺酸吡啶,Potassium Carbonate,间氯过氧苯甲酸,Calcium Carbonate,Copper Dichloride,Palladium Dichloride体系中,用四氢呋喃,甲醇,二氯甲烷,甲苯用作溶剂,-78.0~25.0 °C,101.33 Kpa 条件下,反应 56.0H,反应生成匹伐他汀杂质34
参考文献:Enantioconvergent Synthesis Of A Promising Hmg Coa Reductase Inhibitor Nk-104 From Both Enantiomers Of Epichlorohydrin
标题:Enantioconvergent Synthesis Of A Promising Hmg Coa Reductase Inhibitor Nk-104 From Both Enantiomers Of Epichlorohydrin
摘要:An Enantioconvergent Synthesis Of (+)-Nk-104 (3),A Promising Hmg Co-A Reductase Inhibitor,Has Been Developed From Both Enantiomers Of Epichlorohydrin.
Doi:10.1016/s0957-4166(00)82337-X