2-碘苯甲酸置于tetramethylammonium Hydrogen Sulfate体系中,化学反应 1.0H,以61%的收率获得2,5-二碘苯甲酸 参考文献:Tetraalkylammonium Dichloroiodates As Iodinating Agents: Absence Of Activity In Solid Phases And Superelectrophilic Activity In Sulfuric Acid 标题:Tetraalkylammonium Dichloroiodates As Iodinating Agents: Absence Of Activity In Solid Phases And Superelectrophilic Activity In Sulfuric Acid 摘要:与已发表的结果相反,四烷基铵二氯碘酸盐(alk4N+icl2-)在无溶剂条件下不能作为芳烃的碘化试剂.然而,在硫酸溶液中或在与硫酸中的ag2So4存在下,四烷基铵二氯碘酸盐表现出超亲电子特性,并作为非常方便和高效率的碘化试剂用于非活化芳烃. Doi:10.1055/s-2008-1032026
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-12146028-B2 优先权日:2016-06-06 标 题:Iodo-functionalized polymers as mass spectrometry calibrants with a mass-defect offset 发明人:GRAYSON SCOTT M 权利人:THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND; POLYMER FACTORY SWEDEN AB 摘要:The present invention discloses novel calibrants containing between 1 and 5 iodine atoms and methods of making them using linear polymers, hyperbranched polymers, and biological polymers (including but not limited to proteins and peptides.) Methods of using the calibrants are also disclosed, such as mass spectrometry. The novel calibrants disclosed herein have a more cost- and time-efficient synthesis than other calibrants.
专利号:CN-115785052-A 优先权日:2022-11-21 标题 :A method for highly selective synthesis of isocoumarins under polyacid catalysis
专利号:CN-115785052-B 优先权日:2022-11-21 标 题 :A method for highly selective synthesis of isocoumarin under polyacid catalysis
专利号:CN-110078613-B 优先权日:2019-05-31 标 题 :Synthesis method of 2-halogen-5-iodobenzoic acid
[参考文献]: J A Hamilton, Et Al. The Crystal Structure Of A Complex Of Cycloheptaamylose With 2,5-Diiodobenzoic Acid. Biochem Biophys Res Commun. 1976 Dec 6;73(3):659-64.
合成参考文献
摘要:Journal of Organic Chemistry., 22(1686), 1957 摘要:Pharmazie., 12(415), 1957 []