CAS: 13058-24-7; Trimethyl-[(2-Methylpropan-2-yl)Oxy]Silane

该化合物是一种多用途有机硅化合物,通常在有机合成中用作保护和衍生剂,其主要优点包括与氢氧基组群保持高度回活动,在温和条件下能够有效地保护酒精和苯酚.三丁基组群增强了稳定性,而三甲基硅酸盐有助于容易脱保.这种试剂在peptide合成和碳水化合物化学中特别有用,在这种化学中,选择性保护至关重要.其挥发性和与一系列溶剂的兼容性进一步提高了其在实验室应用中的效用.三丁基甲基硅酸三氧基的可靠性受到重视,因为它在引入具有微量反应的临时保护组时具有可靠性.

结构式图片

欧盟法规

C&L通报

上下游产品

chloro-trimethyl-silane tert-butyl alcoholtert-butyl alcohol O,O-diethyl α-trimethylsilylbenzylphosphonate tert-butylatepotassium tert-butylateethyl trimethylsilyl ether tert-butyl glycidyl ether 1-tert-butoxy-2-trimethylsiloxy ethane 1-formyloxy-2-tert-butoxy ethane

合成工艺路线路线简述

  • 合成目标产物 Tert-Butoxytrimethylsilane 主要起始原料 Hexamethyldisilane And Tert-Butanol
  • (文献来源)合成步骤主要原料 Hexamethyldisilane 和 Tert-Butanol
📜叔丁醇 反应生成叔丁氧基三甲基硅烷
参考文献:Krolevets,A. A.;Antipova,V. V.;Popov,A. G.;Adamov,A. V.,Zh. Obshch. Ximii,58,(1988) N 10,S. 2274-2281
标题:Krolevets,A. A.;Antipova,V. V.;Popov,A. G.;Adamov,A. V.,Zh. Obshch. Ximii,58,(1988) N 10,S. 2274-2281

海关参考信息

专利信息


专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人:BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:US-2003072716-A1
优先权日:2001-06-22
标 题:Renewable, carbohydrate based CO2-philes
发明人:POOVATHINTHODIYIL RAVEENDRAN; WALLEN SCOTT L
摘要:A composition is disclosed comprising a carbohydrate-based material a dispersed in carbon dioxide. A general method for synthesizing inexpensive, renewable, non-toxic, non-fluorous, carbohydrate based CO 2 -philes is disclosed. These CO 2 -philes are soluble in carbon dioxide. Methods of making the composition are also disclosed. The methods and composition are useful in a variety of applications and can utilize gaseous, liquid and supercritical carbon dioxide. The methods and compositions are useful in the synthesis of surfactants and metal chelates for CO 2 , as a sizing substrate, in CO 2 -based coating processes, for impregnation and plasticizing cellulosic and non-cellulosic materials, in pharmaceutical applications, such as crystallization, dispersion and encapsulation of bioactive molecules in solid systems, in the densification of CO 2 , in the synthesis of biodegradable polymers in CO 2 , and for carbon dioxide removal, to name just a few.

专利号:US-6177534-B1
优先权日:1997-12-23
标题 :Silylated resins and the synthesis thereof
发明人:ANTONUCCI JOSEPH M; STANSBURY JEFFREY W; FOWLER BRUCE O
权利人:US COMMERCE
摘要:A silylated resin suitable for use as an adhesive binder for composites and in sealant and adhesive dental applications is represented by the general formula (I): n in which: n R 1 is an aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group; n R 2 is the same as R 1 or a different aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group; n M 2 is the same as M 1 or a different functional or nonfunctional group selected from the group consisting of: n n is 1-3; n x is 1-20; and n y is 1-20; n which comprises the reaction product of the exchange reaction of a hydroxylated, aminated, or carboxylated acrylic resin represented by the general formula (II): n in which: n R 4 is an aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group with one or more protic functional groups selected from the group consisting of: n n n OH, N—H, and CO 2 H n n n R 5 is H or CH 3 ; and n R 6 is H or CH 3 ; n with a trialkoxyorganosilane or triacyloxyorganosilane represented by the general formula (III): n in which: n R 7 , R 8 , and R 9 each is: n R 10 is an aliphatic, or aryl group which can optionally be substituted with a group from the group of an acrylic group, a methacrylic group, an epoxy group, and a substituted amino, hydroxyl, or carboxylic acid group such as an ester or an amide.

专利号:US-2005282898-A1
优先权日:2004-06-01
标 题 :Methods for the synthesis of milnacipran and congeners thereof

专利号:US-2007179100-A1
优先权日:2003-04-09
标 题:Protected monomers
发明人:MANOHARAN MUTHIAH
权利人:MANOHARAN MUTHIAH
摘要:This invention relates to protected monomers for the synthesis of iRNA agents.

专利号:WO-2005118564-A2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Novel Protocol For The Synthesis Of Organic Ammonium Tribromides And Investigation Of 1,1′-(Ethane-1,2-Diyl)Dipiperidinium Bis(Tribromide) In The Silylation Of Alcohols And Thiols
作者:Rupa R. Dey,Bappi Paul,Siddhartha S. Dhar,Sushmita Bhattacharjee |发布日期:2014.10.5
摘要:A Novel And Efficient Protocol For The Synthesis Of Organic Ammonium Tribromides (Oatbs) Is Developed By Using Inexpensive And Eco-Friendly Periodic Acid As An Oxidant For The Conversion Of Br− To Br3−. The Method Does Not Use Any Mineral Acid And Metal Oxidants. The Protocol Is Utilized To Synthesize A New Bis(Tribromide) Viz., 1,1′-(Ethane-1,2-Diyl)Dipiperidinium Bis(Tribromide) (Edpbt). Edpbt Is Investigated As A Catalyst In The Silylation Of Alcohols And Thiols By Hmds (Hexamethyldisilazane) Under Solvent-Free Conditions.

合成参考文献


摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 340.
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