专利号:US-7309799-B2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof 发明人:BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V 权利人:COLLEGIUM PHARMACEUTICAL INC 摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
专利号:US-2003072716-A1 优先权日:2001-06-22 标 题:Renewable, carbohydrate based CO2-philes 发明人:POOVATHINTHODIYIL RAVEENDRAN; WALLEN SCOTT L 摘要:A composition is disclosed comprising a carbohydrate-based material a dispersed in carbon dioxide. A general method for synthesizing inexpensive, renewable, non-toxic, non-fluorous, carbohydrate based CO 2 -philes is disclosed. These CO 2 -philes are soluble in carbon dioxide. Methods of making the composition are also disclosed. The methods and composition are useful in a variety of applications and can utilize gaseous, liquid and supercritical carbon dioxide. The methods and compositions are useful in the synthesis of surfactants and metal chelates for CO 2 , as a sizing substrate, in CO 2 -based coating processes, for impregnation and plasticizing cellulosic and non-cellulosic materials, in pharmaceutical applications, such as crystallization, dispersion and encapsulation of bioactive molecules in solid systems, in the densification of CO 2 , in the synthesis of biodegradable polymers in CO 2 , and for carbon dioxide removal, to name just a few.
专利号:US-6177534-B1 优先权日:1997-12-23 标题 :Silylated resins and the synthesis thereof 发明人:ANTONUCCI JOSEPH M; STANSBURY JEFFREY W; FOWLER BRUCE O 权利人:US COMMERCE 摘要:A silylated resin suitable for use as an adhesive binder for composites and in sealant and adhesive dental applications is represented by the general formula (I): n in which: n R 1 is an aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group; n R 2 is the same as R 1 or a different aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group; n M 2 is the same as M 1 or a different functional or nonfunctional group selected from the group consisting of: n n is 1-3; n x is 1-20; and n y is 1-20; n which comprises the reaction product of the exchange reaction of a hydroxylated, aminated, or carboxylated acrylic resin represented by the general formula (II): n in which: n R 4 is an aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group with one or more protic functional groups selected from the group consisting of: n n n OH, N—H, and CO 2 H n n n R 5 is H or CH 3 ; and n R 6 is H or CH 3 ; n with a trialkoxyorganosilane or triacyloxyorganosilane represented by the general formula (III): n in which: n R 7 , R 8 , and R 9 each is: n R 10 is an aliphatic, or aryl group which can optionally be substituted with a group from the group of an acrylic group, a methacrylic group, an epoxy group, and a substituted amino, hydroxyl, or carboxylic acid group such as an ester or an amide.
专利号:US-2005282898-A1 优先权日:2004-06-01 标 题 :Methods for the synthesis of milnacipran and congeners thereof
专利号:US-2007179100-A1 优先权日:2003-04-09 标 题:Protected monomers 发明人:MANOHARAN MUTHIAH 权利人:MANOHARAN MUTHIAH 摘要:This invention relates to protected monomers for the synthesis of iRNA agents.
专利号:WO-2005118564-A2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof
参考标题:Novel Protocol For The Synthesis Of Organic Ammonium Tribromides And Investigation Of 1,1′-(Ethane-1,2-Diyl)Dipiperidinium Bis(Tribromide) In The Silylation Of Alcohols And Thiols 作者:Rupa R. Dey,Bappi Paul,Siddhartha S. Dhar,Sushmita Bhattacharjee |发布日期:2014.10.5 摘要:A Novel And Efficient Protocol For The Synthesis Of Organic Ammonium Tribromides (Oatbs) Is Developed By Using Inexpensive And Eco-Friendly Periodic Acid As An Oxidant For The Conversion Of Br− To Br3−. The Method Does Not Use Any Mineral Acid And Metal Oxidants. The Protocol Is Utilized To Synthesize A New Bis(Tribromide) Viz., 1,1′-(Ethane-1,2-Diyl)Dipiperidinium Bis(Tribromide) (Edpbt). Edpbt Is Investigated As A Catalyst In The Silylation Of Alcohols And Thiols By Hmds (Hexamethyldisilazane) Under Solvent-Free Conditions.
合成参考文献
摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 340.