📜对硝基苯磺酰氯置于吡啶,Palladium On Activated Charcoal,甲酸铵体系中,用 甲醇 用作溶剂,化学反应生成磺胺苯 参考文献:脲基基团作为基于ureido的阴离子受体中的电子吸收单元:增强的阴离子络合与去质子化. 标题:脲基基团作为基于ureido的阴离子受体中的电子吸收单元:增强的阴离子络合与去质子化. 摘要:磺酰胺基团被用作吸电子基团,以增强基于尿素的受体的阴离子络合特征.合成并彻底测试了一系列磺酰胺基和尿素nh基团的酸度变化的受体.各个络合性质反映了给定分子中作为取代的函数的去质子/络合平衡.含有缀合sulphonamidic部分给电子基团的受体显示出朝向h时缔合常数2 Po 4-和羧酸根阴离子,而那些含有吸电子基团倾向于sulphonamidic N中的去质子化ħ.可以通过在受体合成的早期阶段进行烷基化来避免去质子化问题,也可以将其用于插入合适的基团,从而使其锚定在各种底物上,从而形成更精细的受体结构. Doi:10.1002/cplu.202000326
专利信息
专利号:US-9693999-B2 优先权日:2011-01-26 标题:Small molecule RNase inhibitors and methods of use 发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE 权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education 摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
专利号:WO-2009056955-A1 优先权日:2007-10-30 标题 :Amine-bearing phospholipids (abps), their synthesis and use 发明人:ZUMBUEHL ANDREAS 权利人:UNIV BASEL; ZUMBUEHL ANDREAS 摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.
专利号:US-9868747-B2 优先权日:2014-02-18 标题:Marinopyrrole derivatives and methods of making and using same 发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI 权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD 摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
专利号:US-4136033-A 优先权日:1969-11-07 标 题:6-hydroxypyridone-2 compounds having a cationic group in the 3-position 发明人:STEINEMANN WILLY 权利人:SANDOZ LTD 摘要:Compounds of the formula ##STR1## wherein K.sup.⊕ is a cationic group, preferably heterocyclic, n R is hydrogen or an organic radical, preferably alkyl, phenyl or acyl, n R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, substituted heterocyclyl, amino or substituted amino, and n A.sup.⊖ is an anion, n Are useful as intermediates in the synthesis of azo dyes of the formula ##STR2## wherein D is an aromatic carbocyclic or heterocyclic diazo component radical, and n K.sup.⊕, r, r 1 and A.sup.⊖ are as defined above.
专利号:US-9907753-B2 优先权日:2010-03-19 标 题 :Lipid vesicle compositions and methods of use 发明人:IRVINE DARRELL J; MOON JAEHYUN 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
专利号:US-3062813-A 优先权日:1960-05-13 标题:Novel synthesis of sulfonamides 发明人:SCOTT FRANCIS L 权利人:PENNSALT CHEMICALS CORP