CAS: 116078-65-0; Bidisomide

上下游产品

α-(2-Chlorophenyl)-α-[2-[(1-Methylethyl)Amino]Ethyl]-1-Piperidinebutanamide 116078-64-9
(+/-)-α-(2-Chlorophenyl)-α-<2-<(1-Methylethyl)(Phenylmethyl)Amino>Ethyl>-1-Piperidinebutanamide 116078-63-8
(+/-)-α-(2-Chlorophenyl)-α-<2-<(1-Methylethyl)(Phenylmethyl)Amino>Ethyl>-1-Piperidinebutanenitrile 116078-62-7

📜(+/-)-α-(2-Chlorophenyl)-1-Piperidinebutanenitrile置于pd-Baso4 盐酸,磷酸,硫酸,氢气,Sodium Amide,三乙胺体系中,用 乙醇,氯仿,甲苯 用作溶剂,100.0 °C,548.82 Kpa 条件下,反应 10.5H,反应生成比地索胺
参考文献:一系列抗心律不齐药物的合成与构效关系:二丁胺的一元衍生物.
标题:一系列抗心律不齐药物的合成与构效关系:二丁胺的一元衍生物.
摘要:制备了二元抗心律不齐药二丁胺(2)的类似物,并评估了抗心律不齐药的功效,心肌抑制和抗胆碱能活性.二乙酰丁酰胺中的异丙基被乙酰基取代导致一元类似物sc-40230,7A,表现出非常好的抗心律失常活性,同时心肌抑制和抗胆碱能活性降低.另外,它没有像母体化合物一样引起明显的细胞质液泡.从其他类似物中选择sc-40230作为临床评估的候选物.制备和评估的其他化合物包括吲哚兹丁酮和二丁胺的仲胺异构体.
Doi:10.1021/jm00119A017

专利信息

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.