CAS: 93390-81-9; Fosphenytoin

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CAS号57-41-0 苯妥英 | CAS号93360-07-7 CHLOROMETHYLPHE... | CAS号21616-46-6 3-(hydroxymethy...

📜3-(Chloromethyl)-5,5-Diphenylhydantoin置于palladium On Activated Charcoal 氢气体系中,用 乙酸乙酯,苯 作为反应溶剂,化学反应 2.42H,反应生成 磷苯妥英
参考文献:苯妥英前药iii:口服和/或肠胃外使用的水溶性前药.
标题:苯妥英前药iii:口服和/或肠胃外使用的水溶性前药.
摘要:合成了苯妥英钠的各种生物可逆衍生物,苯妥英钠是口服和胃肠外给药后水溶性差且易失性的药物.对这些预期的前药的初步评估,即它们的水溶性,在各种动物组织中的裂解以及在小鼠中的抗惊厥活性,证实了许多衍生物确实起了前药的作用.最有前途的前药是磷酸二钠酯和3-(羟甲基)-5,5-二苯基乙内酰脲的各种含氨基的酰基酯.
DOI:10.1002/jps.2600730812

专利信息

专利号:US-6376667-B1
优先权日:1997-11-26
标 题 :Solid phase synthesis of heterocycles
发明人：CASTELHANO ARLINDO L; SHAO HUI
权利人:OSI PHARM INC
摘要:Methods and compounds for the synthesis of heterocycles, including pyrimidine-2,4-diones, are disclosed. Also disclosed are solid supports useful for solid phase synthesis, and methods for making the solid supports.

专利号:US-2011040105-A1
优先权日:2008-04-16
标题 :Processes useful for the synthesis of (r)-1--2-methyl-pyrrolidine
发明人：HUBER CHRISTIAN H; KHULMAN YOUNG MI; TANDEL SAGUN K; JOHANNSEN STEPHEN R; WANG TINGMIN; ANGELL PAUL
权利人:ARENA PHARM INC
摘要:Processes useful for making a pharmaceutically useful compound according to Formula (I), forms of such a compound, and intermediates useful in such processes are described.

专利号:WO-2019018655-A1
优先权日:2017-07-19
标题:SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS
发明人：DRIESSCHAERT BENOIT; KHRAMTSOV VALERY
权利人:UNIV WEST VIRGINIA
摘要:The present invention provides compositions and methods relating to paramagnetic probes for EPR spectroscopy. The present invention provides compositions and methods for biocompatible paramagnetic probes that can be targeted to a target in vitro or in vivo, and can provide a monofunctional or multifunctional measurement of a number of physiological parameters of cells or tissue. in vitro or in vivo, individually or in combination. The invention further relates to methods of using the compositions created by the methods of the invention.

专利号:US-2010137244-A1
优先权日:2006-07-13
标题 :Preparation and utility of hmg-coa reductase inhibitors
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described.

专利号:US-8551996-B2
优先权日:2009-02-20
标题 :Compounds, compositions, methods of synthesis, and methods of treatment
发明人：STEHOUWER JEFF; GOODMAN MARK; KILTS CLINT; NEMEROFF CHARLES
权利人:STEHOUWER JEFF; GOODMAN MARK; KILTS CLINT; NEMEROFF CHARLES; UNIV EMORY
摘要:Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).

专利号:US-10092579-B2
优先权日:2016-01-07
标题:Gold(I) complexes with anticancer properties and methods of use thereof
发明人：ALTAF MUHAMMAD; MONIM-UL-MEHBOOB MUHAMMAD; ISAB ANVARHUSEIN ABDULKADIR; ALTUWAIJRI SALEH
权利人:UNIV KING FAHD PET & MINERALS
摘要:Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.