苯乙醚置于aluminum (Iii) Chloride 三乙基硅烷,三氟化硼乙醚体系中,用 乙醚,二氯甲烷,乙腈 作为反应溶剂,化学反应 29.0H,反应生成 4-(5-溴-2-氯苄基)苯酚 参考文献: Cycloalkyl Methoxybenzyl Phenyl Pyran Derivatives As Sodium Dependent Glucose Co Transporter (Sglt2) Inhibitors[fr] Dérivés De Cycloalkyl Méthoxybenzyl Phényl Pyrane En Tant Qu'Inhibiteurs Du Cotransporteur De Glucose Sodium-Dépendant (Sglt2) 标题: Cycloalkyl Methoxybenzyl Phenyl Pyran Derivatives As Sodium Dependent Glucose Co Transporter (Sglt2) Inhibitors[fr] Dérivés De Cycloalkyl Méthoxybenzyl Phényl Pyrane En Tant Qu'Inhibiteurs Du Cotransporteur De Glucose Sodium-Dépendant (Sglt2) 摘要:这项发明涉及环烷基甲氧基苯基吡喃衍生物作为钠依赖型葡萄糖共转运蛋白(sglt)抑制剂,特别是sglt2,以及使用它们治疗受sglt2抑制的疾病,症状和/或疾病的方法,以及它们的制备过程.
专利号:US-9018249-B2 优先权日:2011-09-13 标题 :SGLT inhibitors 发明人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR 权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD 摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).
专利号:US-2014228303-A1 优先权日:2011-06-13 标题 :Novel sglt inhibitors 发明人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR 权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD 摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).