CAS: 86273-18-9; (5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl (2S,5R,6R)-6-[[(2R)-2-Amino-2-Phenylacetyl]Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate

该化合物是一种半合成抗生素,属于青霉素类,主要用于抗菌特性,其特点是能够抑制细菌细胞壁合成,使其对一系列的克抗体和某些克抗菌菌有效. 蓝丙西林经常用于治疗各种感染,包括呼吸道感染,皮肤感染和尿道感染.其化学结构包括一个乙酯环,这是其抗微生物活动必不可少的.该物质通常以盐的形式施用,以提高溶性与生物利用率. 蓝丙西林一般具有良好的耐受性,但与其他抗生素一样,可产生副作用,如过敏反应或胃肠干扰.重要的是,应明智地使用这种抗生素来防止抗生素抗体抗体的发育. 与所有药物一样,其使用应该由保健专业人员指导,考虑到治疗的具体感染和病人的病史等因素.

结构式图片

物理性质

MSDS等安全信息

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-6642377-B1
    优先权日:1999-07-30
    标 题 :Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates
    发明人：KAYANO AKIO; CHIBA HIROYUKI; NAKAMURA TAIJU; SAKURAI SHIN; ISHIZUKA HIROYUKI; SAITO HIROYUKI; KOMATSU YUUKI; SASHO MANABU; SATO NOBUAKI; NEGI SHIGETO
    权利人:EISAI CO LTD
    摘要:A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid:wherein the ring A means the basic antibiotic; R<10 >means a protected functional group used in organic synthesis; Ak-E means the alkali earth metal; and B means the inorganic acid, respectively.

    专利号:CN-1261427-C
    优先权日:2003-08-18
    标 题 :Synthesis of 4,5-dimethyl-1,3-dioxane amylene-2-one

    专利号:CN-115353539-B
    优先权日:2022-07-13
    标题 :Application of oligomeric nucleic acid-tetrahydrothiazole compounds in the synthesis of gene-encoded compound libraries

    专利号:CN-115385973-B
    优先权日:2022-07-13
    标题:Application of oligomeric nucleic acid-tetrahydrothiazole compounds in the synthesis of gene-encoded compound libraries

    专利号:CN-116715639-A
    优先权日:2023-04-24
    标 题 :Synthesis and use of bifunctional molecules targeting HDAC/PD-L1 based on o-phenylenediamine and hydrazides

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    主要参考文献


    1: Sum ZM, Sefton AM, Jepson AP, Williams JD. Comparative pharmacokinetic study between lenampicillin, bacampicillin and amoxycillin. J Antimicrob Chemother. 1989 Jun;23(6):861-8.
    7: Privitera G, Ortisi G, Scarpellini P, Nicastro G, Moro M, Cernuschi M. Impact of lenampicillin on the fecal flora of healthy volunteers. J Chemother. 1989 Jul;1(4 Suppl):600-2. Japanese. Japanese. Japanese. doi: 10.1002/jps.21867. Japanese. Japanese. Japanese. Japanese. Japanese.

    合成参考文献


    参考文献:10.1007/s101560200012
    摘要:Yoshii T, Hamamoto Y, Muraoka S, Furudoi S, Komori T. Differences in postoperative morbidity rates, including infection and dry socket, and differences in the healing process after mandibular third molar surgery in patients receiving 1-day or 3-day prophylaxis with lenampicillin. J Infect Chemother. 2002 Mar;8(1):87–93. doi: 10.1007/s101560200012.
    参考文献:10.1007/s101560200022
    摘要:Kumazawa J, Yagisawa M. The history of antibiotics: the Japanese story. J Infect Chemother. 2002 Jun;8(2):125–33. doi: 10.1007/s101560200022.
    摘要:Sefton AM, Jepson AP, Sun ZM, Williams JD. A comparative pharmacokinetic study between lenampicillin, bacampicillin and amoxycillin. J Chemother. 1989 Jul;1(4 Suppl):494–5.
    摘要:Privitera G, Ortisi G, Scarpellini P, Nicastro G, Moro M, Cernuschi M. Impact of lenampicillin on the fecal flora of healthy volunteers. J Chemother. 1989 Jul;1(4 Suppl):600–2.
    摘要:Miki F, Soejima R. A review of clinical studies on lenampicillin in Japan. J Chemother. 1989 Jul;1(4 Suppl):640–2.
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