CAS: 86060-99-3; Fmoc-Asn-Opfp
该化合物是一块受保护的氨酸衍生物,广泛用于固相聚聚聚丙酸酯(SPPS)组. Fmoc (9-氟氧基碳基)为α-氨基组提供正方位保护,而 OPfp(全氟联苯)酯为高效地与氨合用而激活碳oxyl 组.该化合物因其高度的再活动性和选择性而特别受重视,最大限度地减少链延展期间的侧面反应.其晶体形式确保了处理的稳定性和方便性. Fmoc-Asn-Oppp 在合成合成复合聚物中提供可靠的性能,五氟联苯酯还提高了有机溶剂的溶解性,便利同质反应条件.
- 英文名称Fmoc-Asn-Opfp
- 中文名称N-芴甲氧羰基-L-天冬氨酰胺五氟苯酯
- IUPAC名称perfluorophenyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-asparaginate
- 其它别名Fmoc-L-天冬氨酸五氟苯酯; Nalpha-9-Fluorenylmethoxycarbonyl-L-Asparagine Pentafluorophenyl Ester
- CAS编号86060-99-3
- MFCD编号:MFCD00065625
- 分子式:C25H17F5N2O5分子量:520.41
- 产品CID: 1860732
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
132388-64-8 200622-33-9 86061-00-9物理性质
MSDS等安全信息
上下游产品
CAS号771-61-9 五氟苯酚 | CAS号71989-16-7 Fm°C-L-天冬酰胺 | CAS号113-79-1 精氨酸加压素合成工艺路线路线简述
- 71989-16-7 + 771-61-9 = 86060-99-3
反应条件:1.1 Reagents: 4-Methylmorpholine,9-Fluorenylmethyl Chloroformate; 10 Min,-15 °C1.2 Solvents: Tetrahydrofuran; -15 °C -> Rt
标题:9-Fluorenylmethyl Chloroformate (Fmoc-Cl) As A Useful Reagent For The Synthesis Of Pentafluorophenyl,2,4,5-Trichlorophenyl,Pentachlorophenyl,P-Nitrophenyl,O-Nitrophenyl And Succinimidyl Esters Of Nα-Urethane Protected Amino Acids
作者:Tantry,Subramanyam J.; Babu,Vommina V. Suresh
参考文献:Letters In Peptide Science 日期:2004 卷标:10(5-6) 页码:655-662]
71989-16-7 + 771-61-9 = 86060-99-3
反应条件:1.1 Solvents: 1,4-Dioxane1.2 Solvents: Dimethylformamide1.3 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride1.4 Solvents: Water1.5 Solvents: 1,4-Dioxane
标题:Preparation Of N-9-Fluorenylmethyloxycarbonyl-Asparagine-Pentafluorophenyl Ester From The Free Acid
作者:Gyi,Jeffrey I.; Kinsman,Richard G.; Rees,Anthony R.
参考文献:Synlett 日期:1995 卷标:(2) 页码:205-6
📜五氟苯酚,Fmoc-L-天冬酰胺置于n,N'-二环己基碳二亚胺体系中,用 1,4-二氧六环,N,N-二甲基甲酰胺 作为反应溶剂,以96%的收率获得产物n-芴甲氧羰基-L-天冬氨酰胺五氟苯酯
参考文献:Preparation And Applications Of Pentafluorophenyl Esters Of 9-Fluorenylmethyloxycarbonyl Amino Acids For Peptide Synthesis
标题:Preparation And Applications Of Pentafluorophenyl Esters Of 9-Fluorenylmethyloxycarbonyl Amino Acids For Peptide Synthesis
摘要:
DOI:10.1055/s-1983-30327
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专利信息
专利号:US-2022298204-A1
优先权日:2019-07-05
标题 :Synthesis of a-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.
专利号:EP-3792250-A1
优先权日:2019-09-13
标题:Synthesis of alpha-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.
专利号:JP-2022538692-A
优先权日:2019-07-05
标题 :Synthesis of α-amanitin and its derivatives
专利号:EP-3994146-A1
优先权日:2019-07-05
标题:Synthesis of a-amanitin and its derivatives
专利号:CN-114080395-A
优先权日:2019-07-05
标 题:Synthesis method of alpha-amanitine and derivatives thereof
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📌 第三方产品分析报告
主要参考文献
参考标题:A Novel And Versatile Silicon-Derived Linkage Agent, 4-[1-Hydroxy-2-(Trimethylsilyl)Ethyl]Benzoic Acid, Compatible With The Fmoc/t-Bu Strategy For Solid Phase Synthesis Of C-Terminal Peptide Acids作者:Hann-Guang Chao,Michael S. Bernatowicz,Paul D. Reiss,Clifford E. Klimas,Gary R. Matsueda |发布日期:1994.3
摘要:Solid-Phase Peptide Synthesis. With The Development Of A Versatile Silicon-Based Linkage Agent, «sac», 4-[1-Hydroxy-2-(Trimethylsilyl)Ethyl] Benzoic Acid (1), For The Production Of Peptide C-Terminal Acids, These Problems Have Been Successfully Solved. Demonstration Of The Advantages Of Using Sac Linker Was Provided By Synthesizing A C-Terminal Tryptophan-Containing Dodecapeptide And A C-Terminal Proline-Containing
合成参考文献
参考文献:10.1007/978-94-010-9060-5_310
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