CAS: 77877-20-4; (4R,5S)-4-Methyl-5-Phenyl-3-Propionyloxazolidin-2-One

上下游产品

CAS号77943-39-6 (4R,5S)-(+)-4-甲... | CAS号79-03-8 丙酰氯 | CAS号123-62-6 丙酸酐 | CAS号40626-29-7 右旋盐酸去甲麻黄碱 | CAS号492-39-7 Cathine | CAS号37577-28-9 左旋去甲麻黄碱 | CAS号598-26-5 二甲基乙烯酮 | CAS号24423-87-8 2-oxido-3,4-dih... | CAS号77943-39-6 (4R,5S)-(+)-4-甲... | CAS号16251-45-9 (4S,5R)-(-)-4-甲...

📜去甲伪麻黄碱置于正丁基锂,Potassium Carbonate体系中,用 甲苯 作为反应溶剂,化学反应 2.0H,反应生成 (4R,5S)-3-丙酰基-4-甲基-5-苯基-2-噁唑烷酮
参考文献:Brimble,Margaret A.,Australian Journal Of Chemistry,1990,Vol. 43,# 6,P. 1035-1046
标题:Brimble,Margaret A.,Australian Journal Of Chemistry,1990,Vol. 43,# 6,P. 1035-1046

专利信息

专利号:US-6603015-B2
优先权日:1999-03-29
标题:Synthesis of epothilones
发明人：GEORG GUNDA I; NAIR SAJIV K; REIFF EMILY; TUNOORI ASHOK RAO
权利人:UNIV KANSAS
摘要:Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment A and C precursors. Segment C precursors are prepared using starting nitriles, which can alternately be oxidized to ketones and converted, or reacted to form the diol with subsequent conversion to the segment. Segment A precursors are prepared by reacting a starting enone with a chiral catalyst to give an intermediate alcohol in high enantomeric excess, followed by conversion of the alcohol to the desired Segment A precursor.

专利号:US-7700783-B2
优先权日:2003-10-09
标题 :Synthesis of discodermolide and variants thereof
发明人：SMITH III AMOS B; FREEZE BRIAN SCOTT; XIAN MING
权利人:UNIV PENNSYLVANIA
摘要:Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).

专利号:US-6457303-B1
优先权日:1999-03-29
标题:Synthesis of epothilones
发明人：GEORG GUNDA I; NAIR SAJIV K; REIFF EMILY; TUNOORI ASHOK RAO; HENRI JOHN T
权利人:UNIV KANSAS
摘要:Various epothilone precursors needed for the preparation of final epothilones are provided.

专利号:EP-1058679-B1
优先权日:1998-02-25
标 题 :Synthesis of epothilones, intermediates thereto and analogues therof
发明人：DANISHEFSKY SAMUEL J; BALOG AARON; BERTINATO PETER; SU DAI-SHI; CHOU TING-CHAU; MENG DONGFANG; KAMENECKA TED; SORENSEN ERIK J; KUDUK SCOTT; HARRIS CHRISTINA; ZHANG XIU-GUO; BERTINO JOSEPH R
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.

专利号:US-2002156289-A1
优先权日:1999-03-29
标 题 :Synthesis of epothilones

专利号:US-2002165415-A1
优先权日:1999-03-29
标 题:Synthesis of epothilones