CAS: 7763-16-8; 4-Nitrophenyl ((Benzyloxy)Carbonyl)-L-Glutaminate
该化合物是属于氨基酸衍生物类别的化学化合物,其特点是经苯氧基碳基化合物组和4-硝基苯酯酯酯组群改造的谷类胺基体,其特征是:该化合物有可能在peptide合成中和作为有机化学的保护组群使用,特别是在氨基酸方面;硝基苯组的存在可产生特定的再活动,使其在各种化学变异中有用;此外,苯氧基碳基化合物组可作为一个保护组,在某些条件下可选择性地予以消除,允许在合成过程中操纵谷类胺残留物;该化合物在室温中通常很固,在有机溶剂中可能表现出溶解性;其再活性和功能组体在生物化学应用中具有价值,特别是在聚化物和其他复杂的有机分子的合成中.
- 英文名称4-Nitrophenyl ((Benzyloxy)Carbonyl)-L-Glutaminate
- 中文名称4-硝基苯基((苄氧基)羰基)-L-谷氨酰胺
- IUPAC名称4-nitrophenyl ((benzyloxy)carbonyl)-L-glutaminate
- 其它别名N-Benzyloxycarbonyl-L-Glutamine 4-Nitrophenyl Ester; N-Alpha-Cbz-L-Glutamine P-Nitrophenyl Ester; N-Alpha-Carbobenzoxy-L-Glutamine P-Nitrophenyl Ester; Z-Gln-Onp; Z-Glutamine-Onp; Z-L-Glutamine 4-Nitrophenyl Ester; Z-L-Glutamine P-Nitrophenyl Ester; N-A-Cbz-L-Glutamine P-Nitrophenyl Ester
- CAS编号7763-16-8
- MFCD编号:MFCD00042812
- EINECS号:231-854-4
- 分子式:C19H19N3O7分子量:401.38
- 产品CID: 1770824
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
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MSDS等安全信息
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📜N-苄氧羰基-L-谷氨酸置于氨,N,N'-二环己基碳二亚胺体系中,用 甲醇 作为反应溶剂,化学反应生成 Z-谷氨酰胺对硝基苯酯
参考文献:The Carbohydrate-protein Linkage In Glycoproteins: Part I. The Syntheses Of Some Model Substituted Amides And An L-Seryl-D-Glucosaminide
标题:The Carbohydrate-protein Linkage In Glycoproteins: Part I. The Syntheses Of Some Model Substituted Amides And An L-Seryl-D-Glucosaminide
摘要:描述了n-L-丝氨酸-D-葡萄糖胺,N-甘氨酰-D-葡萄糖胺,N-L-谷氨酰-D-葡萄糖胺和1-O-β-L-丝氨酰-N-乙酰-D-葡萄糖氨基葡萄糖的合成.这些d-葡萄糖胺衍生物可能来自一些糖蛋白的分解.这些化合物的化学性质表明,N-肽在酸性溶液中相对稳定,但在中性和碱性溶液中不稳定.丝氨酰葡萄糖胺在碱性溶液中相对稳定,但在酸性条件下会水解.
DOI:10.1139/v61-125
海关参考信息
- 2902300000-甲苯
2905121000-正丙醇
2905130000-正丁醇
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-4301065-A
优先权日:1977-05-25
标 题 :Novel polypeptides having thymic activity or an antagonistic activity and processes for their synthesis
发明人：BACH JEAN-FRANCOIS; DARDENNE MIREILLE; PLEAU JEAN-MARIE; HAMBURGER JEAN; BRICAS EVANGHELOS; MARTINEZ JEAN; BLANOT DIDIER; AUGER GENEVIEVE
权利人:ANVAR
摘要:The invention is concerned with novel polypeptides and processes for the synthesis thereof. It is concerned with compounds having the sequence X-Gln-Gly-Gly-Y in which Y represents -Ser-Asn and X represents Ser-, Lys-Ser-, Ala-Lys-Ser-, Glx-Ala-Lys-Ser-; Glx representing Pyro-Glu or Gln; and when X represents Glx-Ala-Lys-Ser-, Y may in addition represent -Ser; as well as their derivatives comprising one or two modified amino acids, with the exception of the unmodified compound PyroGlu-Ala-Lys-Ser-Gln-Gly-Ser-Asn. These polypeptides are useful as medicines.
专利号:US-3862113-A
优先权日:1972-09-22
标 题 :Process for the selective elimination of aralkyloxycarbonyl and trityl n-protecting groups with 2,2,2-trifluoroethanol
发明人：RINIKER BERNHARD; KAMBER BRUNO; SIEBER PETER
权利人:CIBA GEIGY CORP
摘要:A process for the selective elimination of amino protective groups in peptide synthesis, wherein the trityl group and/or an aralkyloxycarbonyl group such as the 2-(p-bi-phenylyl)-2propyloxycarbonyl group is (are) split off in trifluorethanol at a pH of about 4 or 1, respectively.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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