CAS: 762-21-0; Diethyl Acetylenedicarboxylate

相似化合物

142-45-0 7218-52-2 31555-05-2

上下游产品

CAS号13677-32-2 diethyl 2,3-dib... | CAS号64-17-5 乙醇 | CAS号928-04-1 2-丁炔二酸单钾盐 | CAS号142-45-0 丁炔二酸 | CAS号137436-73-8 (2,2'-bipyridin... | CAS号137436-75-0 (4,4'-dimethyl-... | CAS号71-43-2 苯 | CAS号1114-31-4 diethyl meso-1,... | CAS号141-52-6 乙醇钠 | CAS号4316-23-8 4-甲基邻苯二甲酸 | CAS号55040-86-3 2-吗啉-4-基-4-苯基噻唑... | CAS号3073-05-0 对五联苯 | CAS号32413-08-4 2,3-喹啉二甲酸二乙酯 | CAS号144537-06-4 diethyl 3-(meth... | CAS号141211-59-8 diethyl 2-[(2-n... | CAS号18352-45-9 diethyl (Z)-2-[... | CAS号563-45-1 异戊烯

Diethyl 2,3-Dibromo-Fumarate置于1,2-Dimethyl-1H-Indazol-2-Ium-3-Carboxylate体系中,用 乙腈 作为反应溶剂,以99%的收率获得产物丁炔二酸二乙酯
参考文献:吲唑的 N-杂环卡宾:α-卤代酮的扩环反应和邻二卤化物的脱卤反应
标题:吲唑的 N-杂环卡宾:α-卤代酮的扩环反应和邻二卤化物的脱卤反应
摘要:在脱羧时,1,2-二甲基吲唑鎓-3-羧酸盐形成 N-杂环卡宾 (L,2-Dimethylindazol-3-Ylidene),使 α-卤代酮去质子化.所得的吲唑盐和相应的烯醇化物形成 1:1 的加合物,其环扩大为 Cinnolines.与 2-Bromo-2,3-Dihydro-1H-Inden-1-One 反应通过扩环反应得到 4-羟基螺[cinnoline-3,2'-Inden]-1'-One(x 射线晶体结构分析)).邻二溴化物在这些条件下脱溴反应生成烯烃,而具有 1,2-二溴乙烯部分结构的底物反应生成乙炔.由于发现3-溴吲唑是该反应的第二个产物,因此提出了由吲唑的n-杂环卡宾夺取br + 引发的e 1Cb 机制.
DOI:10.1055/s-2008-1067215

专利信息

专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人：OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-8957230-B2
优先权日:2011-06-30
标 题 :Synthesis of cleistanthin A and derivatives thereof
发明人：MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
权利人:MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
摘要:The present invention provides a method for preparing Cleistanthin A, a diphyllin glycoside, derivatives thereof and intermediates thereto. In particular the present invention provides in one of the aspect a method for synthesis of compound of formula D a key intermediate of diphyllin, which can be carried out in a shorter duration and at an ordinary temperature.

专利号:US-9650355-B2
优先权日:2013-01-31
标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure
发明人：HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL
权利人:KOREA INST SCI & TECH
摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

专利号:US-5064953-A
优先权日:1983-12-29
标 题:Intermediates cephalosporin derivatives
发明人：OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI
权利人:MOCHIDA PHARM CO LTD
摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

专利号:US-4888332-A
优先权日:1983-12-29
标 题 :Cephalosporin derivatives
发明人：OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI
权利人:MOCHIDA PHARM CO LTD
摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

专利号:US-9850345-B2
优先权日:2012-05-24
标题:Polycarbonate polyol compositions and methods
发明人：FARMER JAY J
权利人:SAUDI ARAMCO TECH CO
摘要:In one aspect, the present disclosure encompasses polymerization systems for the copolymerization of CO 2 and epoxides comprising 1) a catalyst including a metal coordination compound having a permanent ligand set and at least one ligand that is a polymerization initiator, and 2) a chain transfer agent having one or more sites capable of initiating copolymerization of epoxides and CO 2 , wherein the chain transfer agent contains one or more masked hydroxyl groups. In a second aspect, the present disclosure encompasses methods for the synthesis of polycarbonate polyols using the inventive polymerization systems. In a third aspect, the present disclosure encompasses polycarbonate polyol compositions characterized in that the polymer chains have a high percentage of —OH end groups, a high percentage of carbonate linkages, and substantially all polycarbonate chains having hydroxyl end groups have no embedded chain transfer agent.