CAS: 7421-40-1; Carbenoxolone Disodium,(3β,20β)-3-(3-Carboxy-1-Oxopropoxy)-11-Oxoolean-12-En-29-Oicaciddisodium

丁二酸酐,甘草次酸 在 4-二甲氨基吡啶,Sodium Ethanolate体系中,用 甲苯,乙醇作为反应溶剂,以125.1 G的收率获得carbenoxolone Disodium
参考文献:一种甘珀酸钠的制备方法
标题:一种甘珀酸钠的制备方法
摘要:本发明公开了一种甘珀酸钠的制备方法,涉及化工合成技术领域.包括如下步骤:(1)以甘草次酸和丁二酸酐为原料,4‑二甲氨基吡啶为催化剂,甲苯为溶剂反应生成甘珀酸;(2)将甘珀酸用醇钠调碱得到甘珀酸钠.本发明的制备方法反应时间短,成本低,毒性小,有良好的产率和产物转化率,且原料利用率高,操作简单,后处理简单,绿色环保,得到的产品纯度高,含量高.

专利信息

专利号:EP-1886695-A1
优先权日:2006-06-27
标 题:Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
发明人：SCHUMACHER CHRISTOPH
权利人:SPEEDEL EXPERIMENTA AG
摘要:The invention relates to a pharmaceutical combination comprising (a) an aldosterone synthase inhibitor or a pharmaceutically acceptable salt thereof, and (b) a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a cortisol re-synthesis inhibitor or a corticotrophin-releasing hormone receptor antagonist or combinations thereof or in each case a pharmaceutically acceptable salt thereof. Said composition is useful for the manufacture of a medicament, in particular for the manufacture of a medicament for the prevention of, delay of progression of treatment of a disease or condition characterized by the metabolic syndrome.

专利号:WO-9709067-A1
优先权日:1995-09-05
标 题 :Combination of 5-lipoxygenase and leukotriene synthesis inhibitors with glucocorticosteroids
发明人：BURCHARDT ELMAR-REINHOLD; MUELLER-PEDDINGHAUS REINER
权利人:BAYER AG; BURCHARDT ELMAR REINHOLD; MUELLER PEDDINGHAUS REINER
摘要:The combination is disclosed of 5-lipoxygenase inhibitors as direct action lipoxygenase inhibitors (LOI) or of leukotriene synthesis inhibitors (LSI) with glucocorticosteroids (GCS). This combination is suitable for treating and preventing various acute and chronic inflammatory processes, in particular of the respiratory tract, and may therefore be used as a medicament, in particular for treating asthma.

专利号:US-10947273-B2
优先权日:2015-10-09
标 题 :Peptides of use in the preventive and curative treatment of alopecia
发明人：HOCQUAUX MICHEL; ALMEIDA ÉPOUSE SCALVINO STÉPHANIE; LATI ELIAN; BAKALA JOANNA
权利人:INST EUROPEEN DE BIOLOGIE CELLULAIRE; CENTRE DE RECH BIOLOGIQUES ET DEXPERIMENTATIONS CUTANEES; CENTRE NAT RECH SCIENT; INST EUROPEAN DE BIOLOGIC CELLULAIRE
摘要:The object of the present invention relates to a novel family of peptide conjugates of formula (I):n nA-X 1 -X 2 -Pro-Ala-X—B  (I)n wherein:n A represents a hydrogen atom, a C 6 to C 20 acyl group or a cholesterol residue; X 1 represents a covalent bond, an alanine or a proline; X 2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; n or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts,n nas well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.

专利号:US-4381301-A
优先权日:1980-05-07
标题 :Substituted tricyclic thieno compounds, their synthesis, their use, their compositions and their medicaments
发明人：RAINER GEORG
权利人:BYK GULDEN LOMBERG CHEM FAB
摘要:Substituted thienobenzodiazepinones of the general formula I (I) [wherein R1 denotes a hydrogen atom (-H) or an alkyl radical with 1 to 4 carbon atoms; R2 represents a halogen atom (halo) or has one of the meanings of R1; R3 denotes a halogen atom (halo) or the group -N(R4)R5; R4 denotes an alkyl radical with 1 to 4 carbon atoms or an alkenyl radical with 3 to 5 carbon atoms; R5 has one of the meanings of R4 or represents the group -(CH2)m-N(R6)R7; or R4 and R5, together with the nitrogen atom to which both are bonded, denote a morpholino group, a pyrrolidino group, a piperidino group, a hexahydroazepin-1-yl group, a piperazin-1-yl group (which is optionally substituted in the 4-position by a methyl, ethyl or benzyl group), a 2,4-dimethylpiperazin-1-yl group, or a hexahydro-1H-1,4-diazepin-1-yl group (which is substituted in the 4-position by a methyl or ethyl group); R6 denotes an alkyl group with 1 to 4 carbon atoms; R7 denotes an alkyl group with 1 to 4 carbon atoms; A denotes a straight-chain or branched alkylene group with 1 to 5 carbon atoms; and m denotes 2 or 3] and their acid-addition salts are new compounds. They either have a protective action on the stomach and intestine and are suitable for treating illnesses based on disorders of the stomach or intestine, or they are intermediates for preparing products having protective action. Processes for the preparation of the new pharmacologically-active compounds and of the intermediate products are presented.

专利号:WO-2009025888-A2
优先权日:2007-05-10
标 题:Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety

专利号:WO-0026406-A1
优先权日:1998-11-04
标题:METHOD FOR INDEXING AND DETERMINING THE RELATIVE CONCENTRATION OF EXPRESSED MESSENGER RNAs
发明人：HASEL KARL W; HILBUSH BRIAN S
权利人:DIGITAL GENE TECH INC
摘要:An improved method for the simultaneous sequence-specific identification of mRNAs in a mRNA population allows the visualization of nearly every mRNA expressed by a tissue as a distinct band on a gel whose intensity corresponds roughly to the concentration of the mRNA. In general, the method comprises the formation of cDNA using anchor primers to fix a 3'-endpoint, producing cloned inserts from the cDNA in a vector containing a bacteriophage-specific promoter for subsequent RNA synthesis, generating linearized fragments of the cloned inserts, preparing cRNA, transcribing cDNA from the cRNA and performing two sequence specific PCR amplifications of the cDNA. In preferred embodiments, the method comprises comparing the length and at least part of the nucleotide sequence of the PCR products to expected values determined from a database of nucleotide sequences. The method can identify changes in expression of mRNA associated with the administration of drugs or with physiological or pathological conditions. Also provided are vectors and primers useful for the practice of the improved method.