CAS: 69901-75-3; (S)-2-(((Benzyloxy)Carbonyl)Amino)-2-Cyclohexylacetic Acid

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69901-85-5 109183-71-3 14328-51-9

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CAS号14328-51-9 L-环己基甘氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号621-84-1 氨基甲酸苄酯 | CAS号4354-49-8 2-环己基-2-氧亚基乙酸;2...

2-环己基-2-氧代乙酸置于[ruthenium(II)(η6-1-Methyl-4-Isopropyl-Benzene)(Chloride)(μ-Chloride)]2 甲烷磺酸,(R)-(-)-[(S)-2-(Diphenylphosphino)Ferrocenyl]Ethyldi-Tert-Butylphosphine,氢气,三乙胺体系中,用 乙醇,1,2-二氯乙烷,甲苯 作为反应溶剂,25.0 °C,620.53 Kpa 条件下,反应 26.0H,反应生成 Cbz-环己基-L-甘氨酸
参考文献:Asymmetric Hydrogenation Of N-Sulfonylated-α-Dehydroamino Acids: Toward The Synthesis Of An Anthrax Lethal Factor Inhibitor
标题:Asymmetric Hydrogenation Of N-Sulfonylated-α-Dehydroamino Acids: Toward The Synthesis Of An Anthrax Lethal Factor Inhibitor
摘要:[graphic]A Novel And Highly Enantioselective Ru-Catalyzed Hydrogenation Of N-Sulfonylated-Alpha-Dehydroamino Acids Has Been Discovered And Demonstrated In The Synthesis Of An Anthrax Lethal Factor Inhibitor (Lfi). Herein,This Methodology Is Used To Prepare N-Sulfonylated Amino Acids In Up To 98% Ee. This Unprecedented Hydrogenation Uses A Chiral Ru Catalyst Rather Than Rh As Typical For Acylated Dehydroamino Acids And Esters,And This Work Reports The First Asymmetric Hydrogenation Of A Tetrasubstituted Dehydroamino Acid Derivative Using A Ru Catalyst.
DOI:10.1021/ol050869S