CAS: 697300-73-5; 3-Bromo-5-Iodopyridin-2-Amine

相似化合物

381233-96-1 13534-99-1 1186115-39-8

上下游产品

CAS号20511-12-0 2-氨基-5-碘吡啶 | CAS号13534-99-1 2-氨基-3-溴吡啶

📜2-氨基-5-碘吡啶置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 作为反应溶剂,化学反应 72.0H,以47%的收率获得产物3-溴-5-碘-2-吡啶胺
参考文献: Triazolopyridine Compounds[fr] Composés De Triazolopyridine
标题: Triazolopyridine Compounds[fr] Composés De Triazolopyridine
摘要:本发明涉及使用以下式i的新型三唑吡啶衍生物:其中所有变量取代基的定义如本文所述,这些衍生物是syk抑制剂,可用于治疗自身免疫和炎症性疾病.

专利信息

专利号:US-12384788-B2
优先权日:2019-09-13
标 题 :1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
发明人：KOESTLER ROLAND; TASSEL JEAN; THORMANN MICHAEL; YEHIA NASSER; TREML ANDREAS; ALMSTETTER MICHAEL
权利人:ORIGENIS GMBH
摘要:The present invention relates to compounds of formula (I) that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 40 to 146; examples 1 to 63; compounds 1 to 248; tables 1 to 3). Preferred compounds are e.g. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds. An exemplary compound is e.g. 5-(2,6-difluorophenyl)-8-methoxy-1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine (example 49). (Formula (II):