CAS: 697235-49-7; 2-(3-(4-Hydroxyphenyl)Propanamido)Benzoic Acid

主要参考文献

参考标题:Precursor-Directed Combinatorial Biosynthesis Of Cinnamoyl, Dihydrocinnamoyl, And Benzoyl Anthranilates In Saccharomyces Cerevisiae
作者:Aymerick Eudes,Veronica Teixeira Benites,George Wang,Edward E. K. Baidoo,Taek Soon Lee,Jay D. Keasling,Dominique Loqué
摘要:Biological Synthesis Of Pharmaceuticals And Biochemicals Offers An Environmentally Friendly Alternative To Conventional Chemical Synthesis. These Alternative Methods Require The Design Of Metabolic Pathways And The Identification Of Enzymes Exhibiting Adequate Activities. Cinnamoyl, Dihydrocinnamoyl, And Benzoyl Anthranilates Are Natural Metabolites Which Possess Beneficial Activities For Human Health, And The Search Is Expanding For Novel Derivatives That Might Have Enhanced Biological Activity. For Example, Biosynthesis In Dianthus Caryophyllus Is Catalyzed By Hydroxycinnamoyl/benzoyl-Coa:Anthranilate N-Hydroxycinnamoyl/ Benzoyltransferase (Hcbt), Which Couples Hydroxycinnamoyl-Coas And Benzoyl-Coas To Anthranilate. We Recently Demonstrated The Potential Of Using Yeast (Saccharomyces Cerevisiae) For The Biological Production Of A Few Cinnamoyl Anthranilates By Heterologous Co-Expression Of 4-Coumaroyl:Coa Ligase From Arabidopsis Thaliana (4Cl5) And Hcbt. Here We Report That, By Exploiting The Substrate Flexibility Of Both 4Cl5 And Hcbt, We Achieved Rapid Biosynthesis Of More Than 160 Cinnamoyl, Dihydrocinnamoyl, And Benzoyl Anthranilates In Yeast Upon Feeding With Both Natural And Non-Natural Cinnamates, Dihydrocinnamates, Benzoates, And Anthranilates. Our Results Demonstrate The Use Of Enzyme Promiscuity In Biological Synthesis To Achieve High Chemical Diversity Within A Defined Class Of Molecules. This Work Also Points To The Potential For The Combinatorial Biosynthesis Of Diverse And Valuable Cinnamoylated, Dihydrocinnamoylated, And Benzoylated Products By Using The Versatile Biological Enzyme 4Cl5 Along With Characterized Cinnamoyl-Coa- And Benzoyl-Coa-Utilizing Transferases.

合成参考文献

参考文献:10.1016/j.ejpb.2008.04.005
摘要:HEUSCHKEL S, WOHLRAB J, SCHMAUS G, NEUBERT R. Modulation of Dihydroavenanthramide D release and skin penetration by 1,2-alkanediols. European Journal of Pharmaceutics and Biopharmaceutics. 2008 Sep;70(1):239–47. doi: 10.1016/j.ejpb.2008.04.005.