CAS: 65243-33-6; Cefetamet Pivoxil

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CAS号65243-25-6 sodium,(6R,7R)-... | CAS号53064-79-2 特戊酸碘甲酯 | CAS号126617-54-7 δ2-头孢他美 | CAS号65052-63-3 盐酸头孢他美

2,2-Dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-[2-[(2-Chloroacetyl)Amino]-1,3-Thiazol-4-Yl]-2-Methoxyiminoacetyl]Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]oct-2-Ene-2-Carboxylate 反应生成 头孢他美新戊酯
参考文献:Hakao,Xideho;Sugavara,Siniti
标题:Hakao,Xideho;Sugavara,Siniti

专利信息

专利号:US-7452990-B2
优先权日:2002-12-26
标题 :Intermediates for synthesis of cephalosporins and process for preparation of such intermediates
发明人：DATTA DEBASHISH; DANTU MURALIKRISHNA; MISHRA BRIJKISHORE; SHARMA POLLEPEDDI LAKSHMI NARAYANA
权利人:LUPIN LTD
摘要:A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics n nwhereinn n X is chlorine or bromine; R is hydrogen, C 1-4 alkyl group, an easily removable hydroxyl protective group, —CH 2 COOR 5 , or —C(CH 3 ) 2 COOR 5 , wherein R 5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV 1 ), n nwherein X, R and R 5 are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII)n n nin an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.

专利号:US-2006135761-A1
优先权日:2002-12-26
标 题 :Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates

专利号:WO-2004058695-A1
优先权日:2002-12-26
标 题 :Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates

专利号:US-6642377-B1
优先权日:1999-07-30
标 题 :Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates
发明人：KAYANO AKIO; CHIBA HIROYUKI; NAKAMURA TAIJU; SAKURAI SHIN; ISHIZUKA HIROYUKI; SAITO HIROYUKI; KOMATSU YUUKI; SASHO MANABU; SATO NOBUAKI; NEGI SHIGETO
权利人:EISAI CO LTD
摘要:A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid:wherein the ring A means the basic antibiotic; R<10 >means a protected functional group used in organic synthesis; Ak-E means the alkali earth metal; and B means the inorganic acid, respectively.

专利号:EP-1575913-A1
优先权日:2002-12-26
标 题:Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates

专利号:CN-109053628-A
优先权日:2018-08-21
标题 :The friendly process of microwave assisting method synthesis 2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic,thiobenzothiazole ester