CAS: 6404-31-5; ((Benzyloxy)Carbonyl)-D-Proline

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CAS号501-53-1 氯甲酸苄酯 | CAS号344-25-2 D-脯氨酸 | CAS号1148-11-4 N-CBZ-L-脯氨酸 | CAS号136963-32-1 methyl 2,3-dide... | CAS号200499-52-1 (R)-methyl 4-az... | CAS号609-36-9 DL-脯氨酸 | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号205369-12-6 (R)-N-乙酰基-5-溴-3... | CAS号57734-57-3 吡咯烷-2-甲胺 | CAS号72597-18-3 Cbz-D-脯氨醇 | CAS号62937-45-5 D-(-)-脯氨酰胺 | CAS号62937-47-7 (r)-2-甲酰吡咯烷-1-羧酸苯甲酯 | CAS号344-25-2 D-脯氨酸 | CAS号620601-77-6 (R)-1-Cbz-2-氰基-吡咯烷 | CAS号143322-57-0 (R)-5-溴-3-(1-甲基... | CAS号143322-58-1 依来曲普坦 | CAS号143322-56-9 R-3-(N-苄氧基羰基吡咯烷...

(2R)-(+)-Phenylmethyl 2-Formylpyrrolidine-1-Carboxylate置于sodium Chlorite,Disodium Hydrogenphosphate体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 1.0H,以88%的收率获得产物n-苄氧羰基-D-脯氨酸
参考文献:Enantiospecific Syntheses Of (R)-And (S)-Proline And Some Derivatives From D-Glucono-1,5-Lactone
标题:Enantiospecific Syntheses Of (R)-And (S)-Proline And Some Derivatives From D-Glucono-1,5-Lactone
摘要:描述了从之前报道的 D-赤式己酸酯 9 中基于碳水化合物的对映特异性合成 (R)-脯氨酸 1 和 (S)-脯氨酸 2.对衍生自酯 9 的适当活化的中间体进行叠氮取代反应,然后进行还原环化 (H2/pd-C),得到取代的吡咯烷 14 和 22,它们以常规方式转化为相应的 N-Cbz 衍生物 16 和 24.将这些物质进行轻度酸性水解,然后氧化(偏高碘酸钠),得到受保护的脯氨酸 3 和 4,进一步氧化(亚氯酸钠),然后催化氢解,得到脯氨酸 1 和 2. N-Cbz-脯氨醇衍生物还报道了图5和图6.
DOI:10.1039/a704915C

专利信息

专利号:US-8426612-B2
优先权日:2009-04-22
标 题:Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole
发明人：SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO
权利人:SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO; ITALIANA SINT SPA
摘要:The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletriptan or of its salt, comprising the following steps: a) Salifying the intermediate of Formula (6), using a dicarboxylic acid to obtain a derived salt; b) Optionally, purifying said raw salt obtained according to step a) by solvent crystallization to obtain a purified salt of the intermediate of Formula (6); c) Converting said salt of the intermediate of formula (6) according to step a) or said purified salt according to step b) into an intermediate of formula (10); d) Converting the intermediate of Formula (10) into Eletriptan or its salt.

专利号:EP-3819295-A1
优先权日:2019-11-07
标 题 :Stereoselective synthesis of enantiomerically-enriched pantolactone
发明人：BONRATH WERNER; BOURGEOIS FREDERIC; MEDLOCK JONATHAN ALAN; SPARR CHRISTOF
权利人:DSM IP ASSETS BV
摘要:The present invention relates stereoselective synthesis of enantiomerically enriched pantolactone of formula (I) or (I').

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:WO-2010121673-A1
优先权日:2009-04-22
标 题 :Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole

专利号:JP-2012524736-A
优先权日:2009-04-22
标 题 :Synthesis of 3-{[(2R) -1-methylpyrrolidin-2-yl] methyl} -5- [2- (phenylsulfonyl) ethyl] 1H-indole

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.