专利号:US-2009131651-A1 优先权日:2003-12-05 标题 :Synthesis of 2-substituted adenosines 发明人:BROWN GILES ALBERT; SAVORY EDWARD DANIEL; OUZMAN JACQUELINE VALERIE ANNE; STODDART ALISON MARGARET 权利人:BROWN GILES ALBERT; SAVORY EDWARD DANIEL; OUZMAN JACQUELINE VALERIE ANNE; STODDART ALISON MARGARET 摘要:Synthesis of 2-substituted adenosines of formula (I) using 2-nitro pentabenzoyl adenosine, or 2-nitro pentaacetyl adenosine, as intermediate is described: Formula (I) wherein R=C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-4 alkyl, or C 1-4 alkoxy), a benzyloxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy), or a benzoyl group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy). The methods provide improved yield and purity of product.
专利号:US-2016194279-A1 优先权日:2012-12-09 标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas 发明人:CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR 权利人:COUNCIL SCIENT IND RES 摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.
专利号:WO-2012152438-A1 优先权日:2011-05-11 标题 :Process for the preparation of nitrate acid ester of organic compounds 发明人:BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL 权利人:NICOX SA; BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL 摘要:The present invention relates to a one-step process for the synthesis of nitric acid esters or 15 N isotopically labeled nitrate esters of organic compounds starting from the correspondent alcohols. Formula (I).
专利号:US-9593071-B2 优先权日:2011-11-22 标题 :Process for the preparation of gamma amino acids and intermediates used in said process 发明人:ADAMO MAURO 权利人:ROYAL COLLEGE SURGEONS IRELAND 摘要:The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R 1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.
专利号:JP-2003524567-A 优先权日:1997-08-15 标题:Electrical synthesis of hydroxylammonium salt and hydroxylamine using mediator, catalyst film, method for preparing catalyst film, and electrical synthesis of compound using catalyst film
专利号:CA-2552591-A1 优先权日:2003-12-05 标题:Improved synthesis of 2-substituted adenosines
[参考文献]: Lee Chuin Chen, Et Al. Matrix-Assisted Laser Desorption/ionization Mass Spectrometry Using A Visible Laser. Rapid Commun Mass Spectrom. 2007;21(24):4129-34.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 116. 摘要:Schnürch, M.; Hämmerle, J.; Stanetty, P., Science of Synthesis Knowledge Updates, (2010) 1, 159. 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 28(Suppl. 3):217-251, 2009