CAS: 59721-28-7; 4-(2-(2-(Dimethylamino)-2-Oxoethoxy)-2-Oxoethyl)Phenyl 4-Guanidinobenzoate

上下游产品

2-(二甲基氨基)-2-氧代乙基 2-(4-羟基苯基)乙酸酯 2-(Dimethylamino)-2-Oxoethyl 2-(4-Hydroxyphenyl)Acetate 59721-16-3

📜对胍基苯甲酸,2-(二甲基氨基)-2-氧代乙基 2-(4-羟基苯基)乙酸酯置于盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 乙腈 作为反应溶剂,化学反应 5.0H,以38.2 G的收率获得产物卡莫司他
参考文献:一种酰基胍类化合物及其制备方法与应用
标题:一种酰基胍类化合物及其制备方法与应用
摘要:本发明公开了一种具有式i结构的酰基胍类化合物及其药学上可接受的盐.本发明还公开了上述化合物的制备方法,并同时公开了以该化合物或其药学上可接受的盐作为活性有效成分的药物组合物,以及他们在预防或治疗与精氨酸加压素v1A受体,精氨酸加压素v1B受体,精氨酸加压素v2受体相关的疾病(如高血压,慢性充血性心力衰竭,抗利尿激素分泌紊乱综合症或慢性心力衰竭/肝硬化/抗利尿激素分泌紊乱引起的低钠血症)中的应用.

专利信息

专利号:US-2025188022-A1
优先权日:2022-02-07
标 题 :Process for the preparation of nafamostat, camostat and their derivatives
发明人：AHMED RIYAZ; KUMAR GULSHAN; MAHAJAN SHEENA; Verma Praveen Kumar; CHAM PANKAJ SINGH; KUMAR AMIT; AHMED QAZI NAVEED; REDDY DUMBALA SRINIVASA; SHANKAR RAVI; SINGH PARVINDER PAL
权利人:COUNCIL SCIENT IND RES
摘要:The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (Al) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.

专利号:US-2024002405-A1
优先权日:2022-06-01
标题 :Antimicrobial compounds, synthesis methods, and uses thereof
发明人：VERMA RAJNI; DONAVALLI KRISHNA MOHAN; ZAID GENE H
权利人:ANKH LIFE SCIENCES LTD
摘要:Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.