CAS: 59198-70-8; Diflucortolone 21-Valerate

上下游产品

9β,11β-Epoxy-6α-Fluoro-21-Valeroyloxy-16α-Methyl-Pregna-1,4-Diene-3,20-Dione 65535-29-7

📜9β,11β-Epoxy-6α-Fluoro-21-Valeroyloxy-16α-Methyl-Pregna-1,4-Diene-3,20-Dione置于triethylamine Tris(Hydrogen Fluoride)体系中,用98.5%的收率获得产物戊酸双氟可龙
参考文献:9-氟代甾体化合物的合成方法及应用
标题:9-氟代甾体化合物的合成方法及应用
摘要:本发明提供了一种9‑氟代甾体化合物的合成方法及应用,涉及化学合成技术领域.9‑氟代甾体化合物的合成方法,包括如下步骤:化合物ii在含有氟化氢盐的离子液体中反应,得到9‑氟代甾体化合物iii.本发明提供的9‑氟代甾体化合物的合成方法,以含有氟化氢盐的离子液体为氟化剂,代替了传统的氟化氢水溶液,避免氟化氢气体的挥发,腐蚀性小,毒性大幅度降低,且反应条件温和,在室温下即可完成反应,可操作性强,安全系数高,提高了生产适用性.本发明将9‑氟代甾体化合物的合成方法用于制备皮质激素类药物,合成路线中避免使用剧毒的化学试剂,可操作性强,安全系数高,提高了生产适用性.

专利信息

专利号:US-2003157061-A1
优先权日:2001-12-05
标 题 :Combinations of a cyclooxygenase-2 selective inhibitor and a TNFalpha antagonist and therapeutic uses therefor
发明人：BENNETT DENNIS A
权利人:PHARMACIA CORP
摘要:A method for the prevention, treatment, or inhibition of pain, inflammation, or inflammation-related disorder and for the prevention, treatment, or inhibition of a cardiovascular disease or disorder in a subject that is in need of such prevention, treatment or inhibition, involves the administration to the subject of a cyclooxygenase-2 selective inhibitor or prodrug thereof and a TNFα antagonist. A method can also involve the treatment, prevention, or inhibition of cancer in a subject in need of such treatment, prevention, or inhibition, by administering to the subject a cyclooxygenase-2 selective inhibitor or prodrug thereof and a TNFα antagonist which is selected from the group consisting of a compound that affects the synthesis of TNFα, a compound that inhibits the binding of TNFα with a receptor specific for TNFα, and a compound that interferes with intracellular signaling triggered by TNFα binding with a receptor. Compositions, pharmaceutical compositions and kits that can be used with the methods are also described.

专利号:US-8771719-B2
优先权日:2002-08-12
标题 :Synthesis of a bone-polymer composite material
发明人：SHIMP LAWRENCE A; WINTERBOTTOM JOHN M; BOYCE TODD M; KNAACK DAVID
权利人:SHIMP LAWRENCE A; WINTERBOTTOM JOHN M; BOYCE TODD M; KNAACK DAVID; WARSAW ORTHOPEDIC INC
摘要:A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.

专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.

专利号:WO-2024020091-A1
优先权日:2022-07-19
标 题 :Inhibitors of short-chain dehydrogenase activity for reducing glial fibrillary acidic protein levels
发明人：MARKOWITZ SANFORD; PIEPER ANDREW
权利人:UNIV CASE WESTERN RESERVE; THE US GOV AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS
摘要:A method of decreasing blood glial fibrillary acidic protein (GFAP) levels in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor. Astroglia cells are the major and perhaps most abundant cell types in the brain. In healthy brain, astrocytes help with providing structural and network support for neurons and interface with the brain vasculature, including the blood-brain-barrier. Functionally, astrocytes are involved with providing neurotrophic factors (such as glial derived neurotrophic factor (GDNF)), and cytokine/chemokine release that influences the global and local inflammatory response environments, as well as working closely with neurons involved in the glutamate-glutamine synthesis/recycling pathway.

专利号:US-11850220-B2
优先权日:2020-05-19
标题 :Synthesis of ibuprofen hybrid conjugates as anti-inflammatory and analgesic agents
发明人：PANDA SIVA
权利人:UNIV RES INST INC AUGUSTA
摘要:Disclosed herein as ibuprofen hybrid conjugates and methods of their use to reduce inflammation, pain, and fever. The ibuprofen conjugates have potent anti-inflammatory and analgesic properties with low potential for ulcerogenic activity. An exemplary compound is an ibuprofen-amino acid-4-aminophenol hybrid. Also disclosed are methods of treating or reducing inflammation, pain, and fever in a subject.

专利号:US-5567830-A
优先权日:1994-02-14
标题 :Process for synthesis of acetylenic carbinols
发明人：UPASANI RAVINDRA B
权利人:COCENSYS INC
摘要:A method for the preparation of an acetylenic alcohol by reaction of 1,2-dibromoethylene with an alkyl, aryl an heteroaryl lithium in an inert solvent, followed by reaction with a carbonyl-containing compound to give an acetylenic alcohol is disclosed.